相关实验视频
Updated: Jul 12, 2025
05:39
Spontaneous Murine Model of Anaplastic Thyroid Cancer
Published on: February 3, 2023
1.7K
肺状细胞癌 呈现 无塑性淋巴瘤 激酶重排
Kei Sonehara1, Shuhei Nozawa2, Yusuke Suzuki1
1First Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan.
Case reports in oncology
|October 30, 2023
概括
这份病例报告详细介绍了一种罕见的肺脊柱细胞癌与ALK重组. 尽管接受了免疫疗法和ALK抑制剂的治疗,但患者经历了疾病的进展,并最终屈服于疾病.
科学领域:
- 在瘤学瘤学.
- 肺部医学 肺部医学
- 罕见的癌症 罕见的癌症
背景情况:
- 肺状细胞癌是一种罕见的sarcomatoid癌的亚型,预后不佳.
- 在肺部类癌中偶尔会发现亚纳普拉斯性淋巴瘤激酶 (ALK) 的重组,但治疗的有效性仍然不确定.
研究的目的:
- 描述患有ALK重组的晚期肺状细胞癌患者的治疗过程和结果.
- 为了突出管理这种罕见恶性瘤的挑战,使用向治疗和免疫治疗.
主要方法:
- 一个60岁的妇女的病例报告,患有IVB期肺脊柱细胞癌和大脑转移.
- 治疗包括一线 pembrolizumab (免疫疗法),二线 alectinib (ALK 抑制剂),全脑辐射和随后的 ALK 抑制剂.
- 在整个治疗过程中,对临床反应,瘤大小和患者状况进行了监测.
主要成果:
- 第一线 pembrolizumab 没有显著减少原发性瘤大小或改善一般状况.
- 二线阿莱克提尼布导致疾病进展,产生新的大脑转移.
- 随后的治疗,包括全脑辐射和另一种ALK抑制剂,都没有效果.
结论:
- 肺脊柱细胞癌与ALK重组是一种罕见的,具有不良预后的侵袭性瘤.
- 目前的治疗策略,包括免疫疗法和ALK抑制剂,在这种特定的亚型中可能具有有限的疗效.
- 需要进一步的研究来确定有效的治疗方法,用于肺状细胞癌与ALK重组.
更多相关视频
04:04Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer
Published on: February 12, 2017
10.5K
11:15Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors
Published on: September 20, 2016
24.4K
相关概念视频
02:23Abnormal Proliferation
4.5K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.5K
02:19The Spindle Assembly Checkpoint
3.2K
The spindle assembly checkpoint is a molecular surveillance mechanism ensuring the fidelity of chromosome segregation during anaphase. The checkpoint monitors the completion of all the prerequisite steps before chromosome segregation to determine whether the segregation process should proceed or be delayed.
Many proteins function together to control the spindle assembly checkpoint. Mutations affecting these proteins may allow cells to proceed into anaphase prematurely, resulting in the...
Many proteins function together to control the spindle assembly checkpoint. Mutations affecting these proteins may allow cells to proceed into anaphase prematurely, resulting in the...
3.2K