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功能性MRI和扩散张力成像在偏头痛中:对偏头痛功能和白质微观结构变化的审查

Brendon C Chou¹, Alexander Lerner¹, Giuseppe Barisano²

¹Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Journal of central nervous system disease

|October 30, 2023

概括

偏头痛涉及到大脑连接和白质结构的改变. 神经成像研究揭示了偏头痛患者的差异,但一致的发现需要标准化的方法来更好地理解偏头痛病理生理学.

科学领域:

神经科学是一个神经科学.
医疗成像医学成像
神经学神经学

背景情况:

偏头痛是一种复杂的神经疾病,有争议的疾病机制.
了解偏头痛病理生理学对于开发有效的治疗方法至关重要.

研究的目的:

审查和解释功能性MRI (fMRI) 和扩散张力成像 (DTI) 在偏头痛中的发现.
将神经成像结果与偏头痛症状,亚型和阶段联系起来.
扩大对偏头痛病理生理学的理解.

主要方法:

来自PubMed的fMRI和DTI研究的叙事综述.
纳入标准:对偏头痛患者和健康对照者,带有/没有光环的偏头痛患者,以及偶发性和慢性偏头痛患者进行比较.

主要成果:

偏头痛患者在疼痛网络中表现出功能连接 (FC) 和区域激活的改变,根据偏头痛阶段,光环和慢性而有所不同.
观察到白质通道的扩散指数变化,特别是在慢性偏头痛中,与FC变化相关.
功能和微观结构的大脑变化表明疼痛处理和感官过敏的失调.

结论:

神经成像显示了偏头痛患者的功能和微观结构大脑差异.
当前文献中的不一致性凸显了对标准化的fMRI和DTI方法的需求.
结合fMRI和DTI方法可以提供更清晰的偏头痛病理生理学的见解.

关键词:

偏头痛是一种偏头痛.艾拉艾拉艾拉艾拉慢性慢性慢性慢性扩散张力成像扩散张力成像功能性核磁共振成像 (MRI) 的使用.

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