整个中东和北非的人口基因组计划:成功,挑战和未来方向
Hagar Ateia1,2, Pauline Ogrodzki1, Hannah V Wilson2
1G42 Healthcare, Masdar City Abu Dhabi, UAE.
Biomedicine hub
|October 30, 2023
概括
中东和北非 (MENA) 地区的人口基因组计划 (PGPs) 正在增长,解决了遗传数据库的缺口. 挑战仍然存在,但这些举措有望为该地区提供个性化医疗的进步.
科学领域:
- 基因组学就是基因组学.
- 人口遗传学 人口遗传学
- 生物信息学是一种生物信息学.
背景情况:
- 中东和北非 (MENA) 地区面临着大量遗传疾病的负担,在全球遗传数据库中代表性不足.
- 现有的人口基因组计划 (PGPs) 主要集中在其他全球地区,缺乏来自MENA的具体数据.
研究的目的:
- 审查MENA地区PGP的现状.
- 确定正在进行的PGPs,并突出MENA国家基因组计划的挑战和机遇.
主要方法:
- 出版数据的文献综述和人口基因组计划的持续研究.
- 识别和分析MENA地区现有的PGP.
主要成果:
- 在中东和北非地区确定了六个PGP:沙特阿拉伯王国,卡塔尔,埃及,阿拉伯联合长国,巴林和伊朗.
- 中东和北非地区参与国家规模的基因组数据收集正在增加,这导致预计在公共数据库中更大的代表性.
结论:
- 尽管取得了进展,但MENA PGPs面临着挑战,包括合作,资金,基础设施,数据访问,分析,可持续性和生物银行.
- 伦理和受监管的基因组计划对于推进个性化医疗和改善MENA地区患者的治疗结果至关重要.
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