基底前脑活动预测了阿尔茨海默氏病中脑内皮层的功能退化
Marthe Mieling1, Martin Göttlich2,3, Mushfa Yousuf1
1Department of Psychology, University of Lübeck, Lübeck 23562, Germany.
Brain communications
|October 30, 2023
概括
早期阿尔茨海默氏症会影响Meynert (NbM) 活动的基底核,这预测了脑内皮层 (EC) 退化. 这种功能性变化与蛋白质病理学有关,为阿尔茨海默病的病变产生提供了新的见解.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 医疗成像医学成像
背景情况:
- 阿尔茨海默氏病 (AD) 模型涉及梅内尔特基底核 (NbM) 和内腔皮层 (EC) 在早期变性.
- 对于NbM和EC在粉样β和高酸化病理方面的功能作用尚不清楚.
研究的目的:
- 调查NbM和EC在早期阿尔茨海默病中的功能性质.
- 确定NbM和EC中的局部活性是否与AD蛋白病理学 (粉样β和tau) 有关.
- 检查NbM和EC功能活动之间的预测关系.
主要方法:
- 从阿尔茨海默氏病神经成像计划 (ADNI) 队列中分析休息状态功能性MRI (fMRI) 数据 (n=71).
- 功能性MRI测量结果的相关性,特别是低频波动的分数振幅 (fALFF),与脑脊液 (CSF) 生物标志物比率 (粉样β和tau).
- 在2年的时间内进行纵向分析,以评估大脑活动和预测关系的变化.
主要成果:
- 基线fALFF在NbM,但不是EC,在正常和异常的CSFAD生物标志物概况的个体之间进行区分.
- 随着CSFAD生物标志物比率的增加,NbM活动呈现线性下降,反映了疾病状态.
- 基线上的NbM活动预测了EC2年的信号变化率,独立于CSF比率,而EC活动没有预测NbM活动.
结论:
- 梅纳特基底核中的局部活动受到阿尔茨海默氏症蛋白质病理学的影响.
- 梅纳特功能活动的基底核作为早期指标,并预测后续的功能退化在脑内皮层.
- 这些发现为阿尔茨海默病的早期病原发生提供了新的见解,突出了NbM-EC功能连接的作用.
关键词:
阿尔茨海默氏症是阿尔茨海默氏症的一种疾病.基本前脑的前脑.内皮层 (entorhinal cortex) 是一个内侧的皮层.低频波动的分数幅度 (fALFF) 的低频波动.静止状态的fMRI进行.更多相关视频
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