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当前生物药物用于治疗pemphigus foliaceus:一个系统的审查
Caden A Carver1, Mikole Kalesinskas2, A Razzaque Ahmed2,3
1Midwestern University, Arizona College of Osteopathic Medicine, Glendale, AZ, United States.
Frontiers in immunology
|October 30, 2023
概括
利图西马布 (RTX) 和静脉注射免疫球蛋白 (IVIg) 在治疗对传统疗法的不响应的虫 (PF) 方面表现有前途. 这些生物制剂的临床响应率与黄虫 (PV) 的临床响应率相当,有可能改善结果.
科学领域:
- 皮肤病学 皮肤病学
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 皮虫 (Pemphigus foliaceus,简称PF) 是一种皮肤特有的自身免疫性水泡性疾病.
- 传统的治疗包括皮质类固醇和免疫抑制剂 (ISA).
- 有限的文献将PF治疗与pemphigus vulgaris (PV) 隔离开来.
研究的目的:
- 审查当前专门针对尾虫的生物疗法.
- 为临床医生提供关于PF生物治疗的孤立数据.
主要方法:
- 在PubMed,Embase的系统文献搜索中使用关键字:pemphigus foliaceus,rituximab,静脉注射免疫球蛋白,生物药物.
- 包括41项研究,包括105名接受RTX,IVIg或两者的PF患者.
- 对治疗结果,复发率,感染率和死亡率的分析.
主要成果:
- 利图西马布 (RTX) 在63.2%的患者中实现完全缓解 (CR),复发率为39.5%,死亡率为3.9%.
- 静脉注射免疫球蛋白 (IVIg) 在62.5%的患者中实现了CR,没有复发或感染.
- 组合疗法 (RTX然后IVIg) 显示出改善的结果.
结论:
- 对于没有对常规免疫抑制疗法 (CIST) 的反应或具有显著副作用的PF患者,RTX和IVIg是有效的.
- 在PF的RTX结果与光伏的结果相似.
- 特定于PF的协议可以提高结果和生活质量.
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