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48小时常温机器输液与尿液循环再循环用于废弃的人类脏移植

Franka Messner¹, Afschin Soleiman², Dietmar Öfner¹

¹Department of Visceral, Transplant and Thoracic Surgery, Center of Operative Medicine, Medical University of Innsbruck, Innsbruck, Austria.

Transplant international : official journal of the European Society for Organ Transplantation

|October 30, 2023

概括

常温机器输液 (NMP) 成功地保存了被丢弃的人类脏48小时. 这项研究确定了长期NMP期间功能和质量的关键指标.

科学领域:

移植医学移植医学
器官保护科学器官保护科学
脏生理学脏生理学

背景情况:

常温机器输液 (NMP) 已成为器官保存中的一个变革性技术.
了解长时间输液期间移植活性的动态和指标对于改善移植结果至关重要.

研究的目的:

为了调查输液动态,并确定在长时间的正常热机器输液 (NMP) 中丢弃的人类移植物的潜在质量和评估指标.
在NMP下分析输液参数,输液和尿液组成以及异质移植中的损伤标志物.

主要方法:

五个被丢弃的人类移植体经历了48小时的正常热 perfusion (37°C) 使用辅助装置.
使用基于红细胞的输液,并重新循环尿液.
输液动态,输液/尿液组成,以及损伤标志物 (乳酸盐,AST,LDH,细胞因子) 被系统地测量和分析.

主要成果:

在整个48小时的时间内,所有五个脏移植都成功地 perfused.
在整个输液过程中观察到一致的尿液分泌,最终分泌率的中位数为0.43毫升/分钟.
虽然尿液中的含量始终较低,但化物和显示出可变的差异. 乳酸盐,AST,LDH和促炎性细胞因子通常随着时间的推移而增加,特别是在KTX 3和4的移植中.

结论:

外体正常热输液是一种可行的方法,用于评估丢弃的人类脏移植.
NMP可以揭示输液,生物功能和炎症标记物变化的独特模式,有助于评估移植品质.

关键词:

活体外 perfusion perfusion 的意思是生体外 perfusion 的意思.保护脏保护脏机器 perfusion perfusion perfusion 透机是什么? 机器是什么? 机器是什么?对于捐赠脏的正常热机器输液.评价机构的评价机构是评价机构.尿液循环还原尿液循环还原

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