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儿童急性淋巴细胞白血病生存率和墨西哥社会环境风险的空间分析

Jaqueline Calderon-Hernandez^1,2, Lizet Jarquin-Yañez³, Luis Reyes-Arreguin¹

¹Facultad de Medicina/CIAAS, Universidad Autónoma de San Luis Potosi, San Luis Potosi, Mexico.

Frontiers in oncology

|October 30, 2023

概括

包括颗粒物在内的环境暴露与墨西哥的儿童急性淋巴细胞白血病 (ALL) 集群有关. 识别致癌源对于预防策略至关重要,以保护儿童的健康.

科学领域:

环境流行病学环境流行病学
儿科瘤学儿科瘤学
公共卫生公共卫生

背景情况:

急性淋巴细胞白血病 (ALL) 的原因尚未完全理解,但地理和人口统计模式表明环境因素起着作用.
调查环境影响是了解ALL发病率和制定有针对性的预防策略的关键.

研究的目的:

在墨西哥四个城市地区确定童年ALL的集群.
描述与这些ALL集群相关的环境致癌物的来源.

主要方法:

从2015年到2020年,在特定的墨西哥大都会地区分析了443例儿科ALL病例 (儿童<19岁).
利用内核密度分析来识别所有集群并估计过度风险.
估计颗粒物度≤2.5μm (PM2.5) 和,多环芳和PM2.5.5的绘制来源.

主要成果:

确定了七个具有过度风险的显著ALL集群 (RR 1.4-2.3,p < 0.05).
与集群相关的潜在致癌源包括手工炉,加油站,水泥厂和化学制造业.
研究区域的PM2.5水平在15~37μg/m3之间,经常超过世卫组织的指导方针.

结论:

确定了社区一级的ALL集群,可能是由局部致癌源解释的.
高水平的PM2.5显示出严重的空气污染问题,超过了世卫组织的建议.
医疗保健提供者应该教育社区了解环境致癌物附近的所有风险,倡导多部门预防工作.

关键词:

急性淋巴细胞白血病 (ALL)癌症登记册癌症登记册在童年和青春期的青少年.环境暴露环境暴露环境暴露空间分析就是空间分析.

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