美国前列腺癌流行病学和预后因素
Saimaitikari Abudoubari1,2, Ke Bu2, Yujie Mei2
1Department of Radiology, The First People's Hospital of Kashi Prefecture, Kashi, Xinjiang, China.
Frontiers in oncology
|October 30, 2023
概括
这项研究分析了前列腺癌的趋势,并确定了关键的生存因素. 一种新型的诺姆图准确地预测患者的存活率,有助于临床评估和预后.
科学领域:
- 流行病学 流行病学
- 在瘤学瘤学.
- 生物统计学 生物统计学
背景情况:
- 前列腺癌发病率显示稳定的整体趋势,但在特定的人口统计和瘤特征显著转变.
- 了解流行病学模式和预后因素对于改善患者治疗结果至关重要.
研究的目的:
- 分析前列腺癌发病率的流行病学趋势.
- 确定影响前列腺癌特异性生存率的预后因素.
- 开发和验证前列腺癌生存率的预测性名谱.
主要方法:
- 利用监测,流行病学和最终结果 (SEER) 数据库 (1975-2019) 进行趋势分析.
- 收集了来自105,135名前列腺癌患者 (2010-2019) 的临床和随访数据.
- 应用了考克斯回归和阶段回归来进行因子分析,构建和验证名图.
主要成果:
- 整体前列腺癌发病率保持稳定,但在等级,阶段,种族和特定年龄的发病率中观察到显著变化.
- 年龄,瘤阶段,前列腺特异性抗原 (PSA) 和格里森得分被确定为生存的独立风险因素.
- 开发的名图表显示出高的预测准确性 (C指数:0.845培训,0.835验证) 和良好的校准.
结论:
- 尽管总体发病率稳定,但前列腺癌流行病学在不同患者和瘤特征中表现出显著的差异.
- 经过验证的诺米图,包括年龄,瘤阶段,PSA和格里森得分,为预测前列腺癌特异性生存率提供了宝贵的工具.
- 这种预测模型可以帮助临床医生对患者进行评估,诊断和预后评估.
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