与EBV相关的上皮癌的发病和治疗影响
Yi Hua Low1, Celestine Jia Ling Loh1, Daniel Yang Yao Peh2
1Duke-NUS Medical School, Singapore, Singapore.
Frontiers in oncology
|October 30, 2023
概括
爱斯坦-巴尔病毒 (EBV) 驱动各种癌症. 本综述详细介绍了与EBV相关的癌症,包括鼻癌和胃癌,并通过将其与NPC进行比较,提出了罕见的初级肺LELC的致病性.
科学领域:
- 在瘤学瘤学.
- 病毒学 病毒学
- 病变的发生和发病.
背景情况:
- 爱斯坦-巴尔病毒 (EBV) 是一种常见的人类病毒,与淋巴细胞和上皮细胞癌有关.
- 与EBV相关的上皮癌包括未分化的鼻癌 (NPC),与EBV相关的胃癌 (EBVaGC) 和淋巴细胞样癌 (LELC).
- 与EBV相关的NPC的致病性已被理解,但由于其罕见,原发性肺性LELC (PPLELC) 的致病性仍然不清楚.
研究的目的:
- 审查与EBV相关的NPC和EBVaGC的致病性.
- 通过利用与NPC的相似之处来假设PPLELC的病变发生.
- 为了进一步了解EBV相关的瘤发生.
主要方法:
- 关于与EBV相关的NPC和EBVaGC病变发生的文献综述.
- 对NPC和PPLELC病原体的比较分析.
- 基于现有知识,推断PPLELC病原性.
主要成果:
- 已确定的EBV相关NPC和EBVaGC病原体的详细审查.
- 确定NPC和PPLELC之间共享的病原遗传途径.
- 一个针对PPLELC.的病原体的拟议模型.
结论:
- 了解EBV的发病因子对于阐明各种相关癌症至关重要.
- 对比分析提供了对罕见的EBV相关恶性瘤 (如PPLELC) 病变的洞察.
- 进一步研究PPLELC病原体的研究可以通过NPC模型来指导.
相关概念视频
Mechanisms of Retrovirus-induced Cancers
5.1K
Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
5.1K
Mitogens and the Cell Cycle
6.5K
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
6.5K
Tumor Immunotherapy
538
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
538
Rous Sarcoma Virus (RSV) and Cancer
5.1K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
5.1K
Cancer Vaccines
383
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
383
Cytotoxic T Cells-mediated Immune Response
933
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
933


