在性结肠炎患者的恢复性结肠切除术后,炎和便calprotectin之间的关联
Motoi Uchino1, Yuki Horio1, Ryuichi Kuwahara1
1Division of Inflammatory Bowel Disease Surgery, Department of Gastroenterological Surgery, Hyogo Medical University, Nishinomiya, Japan.
Inflammatory intestinal diseases
|October 30, 2023
概括
便中的calprotectin是诊断炎的有用标记物,可用于性结肠炎患者. 升高的水平与疾病活性和治疗反应有显著的相关性.
科学领域:
- 胃肠病学 胃肠病学
- 炎症性肠道疾病是什么
- 临床诊断 临床诊断 临床诊断
背景情况:
- 便calprotectin是性结肠炎疾病活动的确立标记物.
- 之前对便calprotectin用于囊炎评估的研究参与者数量有限.
- 毛囊炎需要可靠的诊断工具来有效管理.
研究的目的:
- 为了前性地评估便中calprotectin水平在囊镜检查期间.
- 分析便calprotectin和囊炎之间的关联.
- 为了确定便calprotectin对囊炎的诊断准确性.
主要方法:
- 在性结肠炎患者的囊镜检查期间,预期测量中calprotectin.
- 基于修改后的囊炎疾病活性指数 (m-PDAI) 评分≥5.5的囊炎诊断.
- 评估便calprotectin,m-PDAI和血清炎症标志物之间的相关性.
主要成果:
- 包括170名患者;72人被诊断患有囊.
- 便中calprotectin水平在患有囊炎的患者 (1,500μg/g) 与没有 (259μg/g) 的患者相比显著更高.
- 在便calprotectin和m-PDAI得分之间发现了显著的相关性 (r2 = 0.279). 截止值为246μg/g,表明诊断的准确性很高 (AUC为0.85).
结论:
- 便calprotectin的升高与囊炎的存在和严重程度有显著的相关性.
- 便中的calprotectin作为一个有价值的非侵入性生物标志物用于诊断囊炎.
- 进一步的研究应该调查在治疗期间便calprotectin水平的变化.
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