在患有纤维肌痛和长期使用阿片类药物的患者中,有害热敏度和时间总和大小之间的相互作用
Jason D Bao1,2, Morgan A Rosser3, Su Hyoun Park1,2
1Human Affect and Pain Neuroscience Laboratory, Department of Anesthesiology, Duke University Medical Center, Durham, NC, United States.
Frontiers in neuroscience
|October 30, 2023
概括
在纤维肌痛中长期使用阿片类药物可能会增加热痛敏感性,可能会影响中央敏感度测量. 需要进一步的研究来了解阿片类药物对慢性疼痛症状的影响.
科学领域:
- 神经科学是一个神经科学.
- 疼痛医学 医学 疼痛医学
- 药理学 药理学是指药理学的学科.
背景情况:
- 中央敏感性是慢性疼痛疾病的关键机制,如纤维肌痛 (FM).
- 长期的阿片类药物治疗是慢性疼痛的常见治疗方法,可能会悖论地恶化中心敏感性.
- 长期使用阿片类药物对FM患者中枢敏感化的影响尚不清楚.
研究的目的:
- 调查长期阿片类药物治疗对纤维肌痛患者中心敏感化的影响.
- 为了比较长期服用阿片类药物的纤维肌痛患者,非阿片类药物的纤维肌痛患者和健康对照者之间的时间总和反应.
- 探索阿片类药物剂量,疼痛敏感性和中央敏感性之间的关系.
主要方法:
- 利用时间总和,通过应用一系列有害的热刺激来验证中央敏感度的测量.
- 评估了三个组的时间总和:长期使用阿片类药物患有FM (阿片类药物-FM,n=24),非阿片类药物使用FM (n=33),和健康对照 (n=31).
- 使用标准问卷收集关于疼痛严重程度和认知情感因素的数据.
主要成果:
- 虽然所有组都显示出类似的时间总和大小,但非阿片类药物的FM患者需要显著降低刺激温度.
- 在结合的 FM 组中,在时间总和和疼痛严重程度之间发现了负相关性.
- 在阿片类药物-FM组中,更高的热痛敏感性随着阿片类药物剂量增加而趋向,这表明潜在的阿片类药物诱导过敏症.
结论:
- 在服用阿片类药物的个体中,时间总和可能受到热痛过敏的影响,可能因阿片类药物的剂量而异.
- 疼痛强度增加可能会影响灵敏度调整的时间总和,这可能会限制其在测量中心敏感度方面的实用性.
- 研究结果表明,长期使用阿片类药物可能会改变纤维肌痛的疼痛处理机制,需要进一步调查.
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