炎症性肠道疾病中的肠道屏障:参考书目和知识图分析
Feng Zhou1, Nan-Zhen Wu2, Yong Xie1
1Department of Gastroenterology, The First Affiliated Hospital of Nanchang University, Nanchang 330000, Jiangxi Province, China.
World journal of gastroenterology
|October 30, 2023
概括
在炎症性肠道疾病 (IBD) 的肠道屏障研究趋势显示了快速的发展. 准肠道微生物群和新陈代谢为改善IBD炎症和预后提供了有希望的治疗策略.
科学领域:
- 胃肠道学和免疫学
- 生物医学研究生物医学研究
- 科学文献分析 科学文献分析
背景情况:
- 表皮屏障表面对于肠道的生理和免疫恒温至关重要.
- 肠道屏障的破坏与炎症性肠道疾病 (IBD) 有关.
- 了解肠道屏障功能是管理IBD的关键.
研究的目的:
- 在IBD的背景下分析肠道屏障研究的发展趋势和研究热点.
- 确定对这一领域做出贡献的关键出版物,机构,作者和期刊.
- 绘制研究主题的演变和兴趣的新兴领域的地图.
主要方法:
- 2002年至2022年间发表的4482篇文章的图书统计分析,来自Web of Science核心集合.
- 使用VOSviewer,CiteSpace和R软件进行数据可视化和分析.
- 确定了高频关键词和新兴研究主题.
主要成果:
- 美国在研究成果方面处于领先地位,芝加哥大学是主要机构.
- 高频关键词包括核因子kappa B,瘤亡因子-α,亡,氧化应激和益生菌.
- 新兴的研究重点是抗氧化剂,Akkermansia muciniphila,纳米粒子,短链脂肪酸和细胞外囊泡.
结论:
- 在IBD的肠道屏障研究领域正在迅速推进,有着重要的国际合作.
- 针对肠道微生物群和饮食代谢,为IBD提供了有希望的治疗途径.
- 认识到肠道屏障的作用为管理炎症和改善IBD患者预后提供了新的视角.
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