相关实验视频
Updated: Jul 12, 2025

10:42
Preparing an Isotopically Pure 229Th Ion Beam for Studies of 229mTh
Published on: May 3, 2019
6.8K
开发225Ac 通过低同位素稀释生产229Th
Jose F Camacaro1, Christopher P Dunckley1, S Elizabeth Harman1
1TerraPower LLC, 15800 Northup Way, Bellevue, Washington 98008, United States.
ACS omega
|October 30, 2023
概括
研究人员开发了一种快速的方法,从-229 (Th) 中分离出高纯度的动-225 (Ac). 这一突破支持针对癌症治疗的向阿尔法疗法的进步.
科学领域:
- 核医学和放射化学的研究.
- 开发有针对性的阿尔法疗法.
背景情况:
- 针对actinium-225 (225Ac) 的阿尔法疗法在癌症治疗中显示出显著的前景.
- 长期以来,生产临床相关量的225Ac一直是一个长期的挑战.
- -229 (229Th) 衰变是一个可行的途径,用于225Ac生产.
研究的目的:
- 描述一种快速加工方案,用于从229Th中分离纯的225Ac.
- 为了实现高产量和225的放射性核/放射性同位素纯度,Ac.
- 为了支持癌症研究和开发工作,以特征的Ac材料.
主要方法:
- 开发一种快速化学分离工艺.
- 从含有228Th活动的229Th源中分离225Ac.
- 每个工艺步骤的表征和最终的225Ac产品.
主要成果:
- 成功分离了225Ac,产量高达98%.
- 实现了225Ac的放射性核和放射性同位素纯度.
- 对225Ac同位素起始材料进行了详细的表征.
结论:
- 已经建立了一种快速有效的方法,可以从229Th中生产高纯度的225Ac.
- 具有特征的225 Ac材料适合推进有针对性的阿尔法疗法研究.
- 这个过程克服了生产225 Ac用于临床应用的挑战.
相关概念视频
Nuclear Transmutation
17.6K
Nuclear transmutation is the conversion of one nuclide into another. It can occur by the radioactive decay of a nucleus, or the reaction of a nucleus with another particle. The first manmade nucleus was produced in Ernest Rutherford’s laboratory in 1919 by a transmutation reaction, the bombardment of one type of nuclei with other nuclei or with neutrons. Rutherford bombarded nitrogen-14 atoms with high-speed α particles from a natural radioactive isotope of radium and observed...
17.6K
Nuclear Stability
18.9K
Protons and neutrons, collectively called nucleons, are packed together tightly in a nucleus. With a radius of about 10−15 meters, a nucleus is quite small compared to the radius of the entire atom, which is about 10−10 meters. Nuclei are extremely dense compared to bulk matter, averaging 1.8 × 1014 grams per cubic centimeter. If the earth’s density were equal to the average nuclear density, the earth’s radius would be only about 200 meters.
To hold positively charged protons together...
To hold positively charged protons together...
18.9K
Radioactive Decay and Radiometric Dating
34.3K
Radioactivity is a spontaneous disintegration of an unstable nuclide and is a random process, as all the nuclei in the sample do not decay simultaneously. The number of disintegrations per unit time is called the activity (A), which is directly proportional to the number of nuclei in the sample. The decay constant (λ) is an average probability of decay per nucleus in unit time.
34.3K
Isotopes and Radioisotopes
8.6K
In the early 1900s, English chemist Frederick Soddy realized that an element could have atoms with different masses that were chemically indistinguishable. These different types are called isotopes — atoms of the same element that differ in mass. Isotopes differ in mass because they have different numbers of neutrons but are chemically identical because they have the same number of protons. Soddy was awarded the Nobel Prize in Chemistry in 1921 for this discovery.
An isotope containing...
An isotope containing...
8.6K

