开发,表征和Neomycin-Loaded粘土增强纳米纤维的烧伤伤愈合潜力
Badriyah Shadid Alotaibi1, Abida Kalsoom Khan2, Munaza Ijaz3
1Department of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia.
ACS omega
|October 30, 2023
概括
载有胺素的纳米纤维 (NCPP) 已经成功地被制造出来,以促进伤口愈合. 这些纳米纤维在子伤口模型中表现出显著的抗菌活性和改善愈合.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术 纳米技术
- 伤口治愈研究研究 伤口治愈研究
背景情况:
- 全球有数百万人患有皮肤伤口,需要具有成本效益的治疗方法.
- 目前的伤口护理策略经常面临有效性和患者遵守方面的挑战.
研究的目的:
- 用于制造含有neomycin的奇托-凝/聚乙烯醇/聚烯 (CG/PVA/PAN) 纳米纤维 (NCPP),以改善伤口愈合.
- 评估NCPP纳米纤维的物理化学,抗菌和体内伤口愈合特性.
主要方法:
- 使用TGA,SEM,FTIR和XRD进行的NCPP纳米纤维的特征.
- 评估药物的溶解性,溶解,胀,侵蚀和抗菌活性.
- 在子体内通过百分比的伤口关闭和组织病理学评估伤口愈合.
主要成果:
- SEM显示了纤维聚合;TGA表明药物载入纳米纤维的增强稳定性 (10%).
- 观察到15%PVA配方的受控药物释放;NCPP纳米纤维表现出良好的保留水分.
- 对 *Enterococcus faecalis* 和 *Klebsiella肺炎* 有显著的抗菌活性.
结论:
- NCPP纳米纤维成功制造,稳定性提高,药物释放受控.
- 在子模型中表现出显著的抗菌特性和加速伤口愈合.
- NCPP纳米纤维显示出治疗受感染的皮肤伤口的前景.
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