在患有严重COVID-19和肺血栓事件的患者中发现了新的炎症标志物
Jarosław Bakiera1, Karolina Strzelec-Pawełczak2, Katarzyna Czarnek3
1Department of Laboratory Diagnostics, Coagulation and Microbiology, Stefan Wyszyński Regional Specialist Hospital, Lublin, Poland.
Central-European journal of immunology
|October 30, 2023
概括
静脉血栓栓塞 (VTE),包括肺栓塞 (PE),是COVID-19患者的重大风险. 新的炎症生物标志物,如中性粒细胞与淋巴细胞的比率,可以帮助评估这种风险.
科学领域:
- 心脏病学 心脏病学
- 肺部病理学 肺部病理学
- 血液学 血液学 血液学
背景情况:
- 静脉血栓塞栓症 (VTE),包括深静脉血栓症 (DVT) 和肺栓塞 (PE),是主要的心血管事件.
- 随着年龄的增长,PE发病率显著增加,不成比例地影响老年人群.
- COVID-19已与血栓事件的风险增加有关.
研究的目的:
- 为了确定住院COVID-19患者肺栓塞 (PE) 的发生率.
- 在COVID-19期间经历肺血栓事件的患者中研究新型炎症生物标志物的实用性.
主要方法:
- 对226名COVID-19患者进行了回顾性研究.
- 对经历了肺血栓事件的患者的分析.
- 评估中性粒细胞与淋巴细胞的比率和血小板与淋巴细胞的比率.
主要成果:
- 住院COVID-19患者中PE的发生率估计为1.9-8.9%.
- 中性细胞与淋巴细胞的比率和血小板与淋巴细胞的比率被强调为潜在的有价值生物标志物.
- 追溯设计和短暂的观察期可能导致低估了PE发病率.
结论:
- COVID-19患者面临着肺栓塞的显著风险.
- 炎症生物标志物,特别是中性粒细胞与淋巴细胞和血小板与淋巴细胞的比率,在评估COVID-19中血栓形成风险方面表现有前途.
- 这些新的生物标志物可以补充PE评估的现有诊断工具.
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