我们是否应该重新考虑对老年患者的123 I-Ioflupane研究进行甲状腺阻塞:量化未被阻塞的甲状腺辐射剂量以及对临床实践的含义
D William A Morton1, Nicholas Vennart1, Harry Slinger1
1Department of Medical Physics, South Tyneside and Sunderland NHS Foundation Trust, Sunderland and .
Nuclear medicine communications
|October 30, 2023
概括
对所有接受123I-Ioflupane的患者来说,甲状腺阻塞可能不需要. 该研究发现甲状腺剂量低于推值,建议重新考虑老年患者的预防,因为诱导的高甲状腺/低甲状腺症 (IIH) 的风险.
科学领域:
- 核医学就是核医学.
- 放射性药理学 是一种放射性药理学.
- 医疗成像医学成像
背景情况:
- 123I-Ioflupane 在诊断成像中使用.
- 甲状腺阻塞预防是减轻甲状腺辐射剂量的标准做法.
- 在所有患者中,甲状腺阻塞的必要性需要评估.
研究的目的:
- 在没有甲状腺预防的情况下接受123I-Ioflupane的患者中测量甲状腺吸收剂量.
- 为了比较甲状腺辐射暴露与预防中过量剂量的风险.
- 确定甲状腺阻塞是否应仅限于特定的患者群体,特别是老年人.
主要方法:
- 一组30名没有接受甲状腺预防的患者在123I-Ioflupane给药后接受了静态甲状腺成像.
- 测量了自由123I的甲状腺摄取量,并推断到峰值摄取量.
- 用MIRD方法计算了吸收的甲状腺剂量.
主要成果:
- 甲状腺吸收的平均剂量为13.6 mGy (SD 8.8 mGy).
- 这一剂量为有效剂量增加了额外的0.5mSv.
- 观察到的最大甲状腺剂量为36.3mGy,低于预防的50mGy建议剂量.
结论:
- 这项研究表明,123I-Ioflupane的甲状腺吸收剂量可能不需要常规的预防性甲状腺阻塞.
- 从预防中引起的过高/低甲状腺症 (IIH) 的风险,特别是老年人,应该与辐射风险相对衡量.
- 建议对接受123I-Ioflupane的老年患者重新考虑胺预防.
更多相关视频
09:49A Whole Body Dosimetry Protocol for Peptide-Receptor Radionuclide Therapy PRRT: 2D Planar Image and Hybrid 2D+3D SPECT/CT Image Methods
Published on: April 24, 2020
10.0K
06:52Positron Emission Tomography Using 64-Copper as a Tracer for the Study of Copper-Related Disorders
Published on: April 28, 2023
1.4K
相关概念视频
02:59Biological Effects of Radiation
15.5K
All radioactive nuclides emit high-energy particles or electromagnetic waves. When this radiation encounters living cells, it can cause heating, break chemical bonds, or ionize molecules. The most serious biological damage results when these radioactive emissions fragment or ionize molecules. For example, α and β particles emitted from nuclear decay reactions possess much higher energies than ordinary chemical bond energies. When these particles strike and penetrate matter, they...
15.5K
01:30Radiological Investigation I: X-ray and CT
253
Radiological investigations, including X-rays and computed tomography (CT) scans, are critical for diagnosing and evaluating various medical conditions. These imaging techniques provide valuable insights into the body's internal structures, aiding in the detection of abnormalities, assessment of disease progression, and development of treatment strategies. This article delves into two primary radiological investigations, chest X-rays and CT scans, outlining their purpose, procedures, and...
253
01:25Imaging Studies II: Positron Emission Tomography and Scintigraphy
130
Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
Fundamental Principles of PET
130