炎症过程对发育中的中枢神经系统的影响在儿童发作的全身性红斑狼中
Hanne van der Heijden1, Vanessa Rameh2, Emma Golden2
1Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, and University of Amsterdam, Amsterdam, The Netherlands.
Arthritis & rheumatology (Hoboken, N.J.)
|October 30, 2023
概括
儿童开始的全身性红斑狼 (cSLE) 患者由于慢性炎症影响其发育中的大脑,经历了严重的神经精神问题. 早期发现和干预对于改善终身健康结果至关重要.
科学领域:
- 儿科风湿病学 儿科风湿病学
- 神经免疫学 神经免疫学
- 自免疫性疾病 自免疫性疾病
背景情况:
- 系统性红斑狼 (SLE) 是一种慢性自身免疫性疾病,影响儿童和成人人口.
- 神经精神表现 (NPM) 较严重,在儿童发病的SLE (cSLE) 中的预后较差,而不是成人发病的SLE.
- 在cSLE中的NPM显著损害了学校的功能,自我管理,心理健康和长期的生活质量.
研究的目的:
- 审查cSLE中中枢神经系统 (CNS) 现型背后的致病机制.
- 讨论中枢神经系统障碍物变化的作用,如血脑屏障,在cSLE.
- 突出新型神经成像发现,用于检测cSLE中微妙的中枢神经系统异常.
主要方法:
- 审查关于cSLE病原机制的现有文献.
- 讨论新型神经成像技术的发现.
- 分析慢性炎症对中枢神经系统发育的影响.
主要成果:
- 假设不适应性炎症过程和缺血在cSLE中驱动中枢神经系统表型.
- 中枢神经系统屏障的改变,包括血脑屏障,有助于神经精神症状.
- 新型神经成像方法可以检测中枢神经系统的异常,而传统的MRI无法检测到.
结论:
- 在cSLE患者中,发育中的中枢神经系统特别容易受到慢性炎症攻击,导致严重的NPM.
- 需要紧急开发诊断工具和治疗方法,以减轻促炎状态对未成熟的中枢神经系统的影响.
- 需要进一步研究cSLE中中枢神经系统和其他受影响器官系统之间的相互连接.
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