系统性炎症的预后值,以及患有结直肠癌缓解症的患者
Guo-Tian Ruan1,2,3,4, Hai-Lun Xie1,2,3, Kai-Tao Yuan5
1Department of Gastrointestinal Surgery, Department of Clinical Nutrition, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
Journal of cachexia, sarcopenia and muscle
|October 30, 2023
概括
系统性炎症标志物如C反应蛋白 (CRP) 和性能状态 (ECOG-PS) 预测结直肠癌 (CRC) 缓解症患者的存活率. 结合这些提供了一个简单的预后工具,用于CRC缓解症.
科学领域:
- 在瘤学瘤学.
- 炎症研究 炎症研究
- 预测生物标志物 预测生物标志物
背景情况:
- 癌症缓冲症与炎症和减少身体功能有关.
- 在结直肠癌 (CRC) 缓解症中生存的预后预测仍然具有挑战性.
- 这项研究探讨了系统性炎症和性能状况作为CRC缓解症的预测因素.
研究的目的:
- 调查CRC缓解症患者的全身炎症和表现状况的预后价值.
- 确定可靠的炎症标志物用于CRC的生存预测.
- 评估东部合作瘤集团 (ECOG-PS) 的绩效评分作为一个风险因素.
主要方法:
- 一个多中心前性队列研究905个CRC患者.
- 使用2011年费伦标准诊断的癌症缓解症.
- 预后值通过AUC,C指数和Cox回归来评估炎症标志物 (CRP,LCR,CAR) 和ECOG-PS.
主要成果:
- 甲基C反应蛋白 (CRP),淋巴细胞与CRP比率 (LCR) 和CRP与白蛋白比率 (CAR) 的预后值稳定.
- 高度炎症 (低LCR,高CAR,高CRP) 和表现不佳状态 (ECOG-PS 2-4) 与CRC缓解症的更差预后有关.
- 患有CRC缓解症和高炎症/低ECOG-PS的患者的存活时间明显缩短.
结论:
- 系统性炎症标志物LCR,CAR和CRP是CRC中稳定的预后指标.
- 对于CRC来说,ECOG-PS是一种潜在的独立风险因素.
- 系统性炎症和ECOG-PS的综合评估为CRC缓解症患者提供了简单的生存预测.
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