经关节跨septal过导管中枢替换后的一年结果:无畏的TMVR早期可行性研究结果
Firas Zahr1, Howard K Song1, Scott Chadderdon1
1Oregon Health and Science University, Portland, Oregon, USA.
JACC. Cardiovascular interventions
|October 30, 2023
概括
透导管 mitra 置换 (TMVR) 为患有 mitra 吐的高风险患者提供了一种安全有效的替代方案. 在一年后,Intrepid系统显示了持续的好处,包括低死亡率和改善功能状态.
科学领域:
- 心血管医学 心血管医学
- 干预心脏病学 干预心脏病学
- 医疗器械 医疗器械
背景情况:
- 高度的外科风险往往限制了对心心替换的选择.
- 透导管 mitra 置换 (TMVR) 是一种新的方法来治疗高风险患者的 mitra 吐 (MR).
研究的目的:
- 评估IntrepidTMVR系统的30天和1年的结果.
- 在患有中度至重度腹的患者中评估了安全性和有效性.
主要方法:
- 展望性,多中心,单臂可行性研究.
- 33名中度至重度MR患者通过输穿接入接受TMVR.
- 根据米特拉学术研究联盟的标准评估的终点.
主要成果:
- 在93.9%的患者中成功植入.
- 在30天:没有死亡/中风,低血管并发症. 一年后:所有原因死亡率为6.7%,≤轻度MR,没有/没有痕迹的膜漏洞.
- 91.7%的NYHA功能类I/II的幸存者生活质量有所改善.
结论:
- 无畏TMVR系统显示持续的早期好处长达1年.
- 展示了有利的安全性,低的重新干预率和耐用的门功能.
- 提供了一个可行的治疗选择,高风险的患者与 mitrale 吐.
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