儿童科根综合征伪装成IgA血管炎
Praveen K Ramani1, Florin Grigorian2, Heidi Lightle3
1Department of Pediatric Neurology, Arkansas Children's Hospital, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
儿科科根综合征是一种罕见的自身免疫性血管炎,可以模仿儿童的IgA血管炎. 早期识别眼睛和听觉症状对于及时诊断和预防永久性残疾至关重要.
科学领域:
- 儿科风湿病学 儿科风湿病学
- 自免疫性疾病 自免疫性疾病
- 血管炎是一种血管炎.
背景情况:
- 儿科科根综合征是一种罕见的自身免疫性血管炎,影响眼睛和耳朵.
- 它的诊断和管理仍然不清楚.
- 在儿科患者中,它往往被忽视.
研究的目的:
- 报告一种模仿IgA血管炎的非典型儿科科根综合征病例.
- 强调在IgA血管炎后出现新的眼睛或前体症状的儿童中识别科根综合征的重要性.
- 强调早期诊断和多学科管理的必要性.
主要方法:
- 一个12岁女孩的病例报告,最初的IgA血管炎症状.
- 诊断工作排除了传染病和其他类风湿性疾病.
- 多学科管理涉及风湿病学,眼科,耳鼻喉科和听力学.
主要成果:
- 患者出现了前性耳膜炎和渐进的双侧神经神经听力损失,导致诊断为非典型的柯根综合征.
- 之前的脑膜炎对全身葡萄皮质类药物和甲醇酸有反应.
- 听力损失的进展,需要一个耳植入物.
结论:
- 儿科科根综合征可以呈现为IgA血管炎的模仿者.
- 临床医生应考虑在IgA血管炎后出现新的眼睛或前庭问题的儿科患者中考虑Cogan综合征.
- 早期识别和干预对于预防由于缺乏明确的诊断标准而导致的永久性残疾至关重要.
更多相关视频
06:35An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
Published on: February 8, 2019
10:24Detecting Abnormalities in Choroidal Vasculature in a Mouse Model of Age-related Macular Degeneration by Time-course Indocyanine Green Angiography
Published on: February 19, 2014
相关概念视频
Transcytosis of IgG
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
Gastritis-II: Pathophysiology
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
Other Disorders of Digestive System
Inflammatory Bowel Disease II: Crohn's Disease
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Barrett Esophagus-II: Clinical Manifestations and Management
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
Gastritis III: Clinical Manifestations and Management
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...
