根源性囊切除术后的长期生存结果的预测模型
Akira Ohtsu1, Seiji Arai1, Yuji Fujizuka1
1Department of Urology, Gunma University Graduate School of Medicine, Maebashi, Japan.
Cancer medicine
|October 30, 2023
概括
冈玛大学瘤学研究小组 (GUOSG) 的新得分预测了膀癌激进囊切除术后的生存率. 这种工具有助于个性化预后和评估侵袭性膀癌的新疗法.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 在瘤学瘤学.
- 癌症研究 癌症研究
背景情况:
- 对于激进囊切除术后危及生命的复发的预测模型是侵入性膀癌管理所需的.
- 激进囊切除术是侵袭性膀癌的关键治疗方法.
研究的目的:
- 开发一个用户友好的预测模型,用于激进囊切除术后的结果.
- 确定影响整体生存 (OS),癌症特异性生存 (CSS) 和无复发生存 (RFS) 的因素.
主要方法:
- 对204名接受开放激进囊切除术 (ORC) 的患者进行了回顾性分析.
- 提取临床病理学和外科手术期间的数据.
- 考克斯回归分析以确定OS,CSS和RFS的显著预测因素.
主要成果:
- 五年的RFS,CSS和OS分别为66.5%,77.6%和75.4%.
- 病理T/N类别,淋巴血管入侵 (LVI),临床T类别,年龄和ORC瘤等级是显著的预测因素.
- 开发的冈玛大学瘤学研究小组 (GUOSG) 评分有效地将患者分为RFS,CSS和OS的不同风险组.
结论:
- GUOSG评分为患者提供了个性化的预后.
- 这个模型作为一个风险分层队列来评估新的救援治疗的有效性.
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