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与细胞癌风险相关的循环炎性细胞因子:一个性别特异的双样本孟德尔随机化研究

Shuixiang Tao¹, Yiwei Lin², Shengqiang Huang³

¹Department of Urology, Shaoxing People's Hospital (Zhejiang University Shaoxing Hospital), Shaoxing, Zhejiang, China.

Cancer medicine

|October 30, 2023

概括

高水平的Eotaxin会导致男性增加细胞癌 (RCC) 的风险,但女性不会. 这一发现可能有助于未来的RCC诊断和治疗策略.

科学领域:

在瘤学瘤学.
遗传学遗传学是一个
免疫学免疫学免疫学

背景情况:

细胞癌 (RCC) 缺乏用于诊断和治疗的特定分子生物标志物.
识别新的生物标志物对于改善患者的治疗结果至关重要.

研究的目的:

系统地评估循环细胞因子对RCC风险的因果作用,使用性别特定的方法.
调查细胞因子与RCC之间的关系中的潜在性别差异.

主要方法:

采用了两个样本的孟德尔随机化分析.
使用 cis-定量特征位点 (cis-QTLs) 作为细胞因子水平的仪器变量.
评估了细胞因子对男性和女性RCC风险的因果影响.

主要成果:

在男性中较高的Eotaxin水平和增加的RCC风险之间发现了显著的因果关系 (OR=2.546,P=5.496×10−5).
在女性中没有观察到Eotaxin对RCC风险的显著因果作用.
其他细胞因子如RANTES,MCP3,PDGFbb,TRAIL (雄性) 和sICAM,SCGFb (雌性) 显示出潜在的关联.

结论:

循环Eotaxin与男性的RCC风险增加有因果关系,但女性没有.
需要进一步的研究来探索这些发现在RCC预后和治疗中的潜在机制和临床应用.

关键词:

毒素 (Eotaxin) 是一种有毒的物质.门德尔的随机化细胞因子细胞因子细胞癌瘤是细胞癌.

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