下泌尿道如何促进膀的感觉? 在ICI-RS 2023年发布
Luke Grundy1, Jean J Wyndaele2, Hikaru Hashitani3
1Neurourology Research Group, Flinders Health and Medical Research Institute, Flinders University, South Australia, Australia.
Neurourology and urodynamics
|October 30, 2023
概括
了解膀的感觉是健康膀功能的关键. 需要对膀感官信号机制进行进一步的研究,以改善治疗过度活跃膀 (OAB) 和膀疼痛综合征 (BPS) 等疾病的方法.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 神经科学是一个神经科学.
- 生理学 生理学 生理学
背景情况:
- 膀感觉对于自愿排尿和保持膀健康至关重要.
- 感官信号来源于刺激膀壁的 afferents,但底层的生理复杂性尚未完全理解.
- 功能失调的膀感觉有助于诸如过度活跃的膀 (OAB) 和间歇性囊炎/膀疼痛综合征 (IC/BPS) 等疾病.
研究的目的:
- 审查关于膀感官信号传递机制的当前知识.
- 确定关键的研究领域,以推进对健康和疾病中的膀感觉的理解.
- 为改善膀疾病治疗策略的开发提供信息.
主要方法:
- 膀感官信号专家的文献评论.
- 在第十届关于失禁研究协会的国际咨询会议上讨论了关键研究领域.
- 综合当前对下泌尿道对膀感觉的贡献的理解.
主要成果:
- 对于理解神经对膀充满感觉的贡献 (尾,骨盆,腹下) 存在知识差距.
- 伸展敏感 (肌肉) 与伸展不敏感 (粘膜) 的作用需要进一步阐明.
- 肌肉粘膜和尿道因素对膀感觉和功能的影响需要更多的研究.
结论:
- 膀感觉信号的干扰可以导致像OAB和IC/BPS这样的衰弱状况.
- 对膀感觉产生机制的更好理解对于治疗进步至关重要.
- 已经确定了具体的研究领域,以解决当前的知识缺口.
相关概念视频
Anatomy of the Genitourinary System II: Bladder and Urethra
125
The lower urinary system consists of the urinary bladder and urethra, which are essential in storing and expelling urine from the body. Together with the internal and external sphincters, these structures work together to regulate urination effectively.Anatomy of the BladderThe urinary bladder is a muscular, stretchable organ behind the pubic bone and in front of the rectum. In females, the bladder is positioned anterior to the vagina and inferior to the uterus, while in males, it is located...
125
Urinary Bladder
832
The urinary bladder is a hollow, muscular sac that temporarily stores urine before it is expelled from the body. It can hold approximately 600 mL of urine prior to micturition. The bladder is retroperitoneal and located behind the pubic symphysis in the pelvic floor.
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
832
The Micturition Reflex
678
Urination, or micturition involves the coordination of the bladder's detrusor muscle and two sphincters to ensure controlled bladder emptying.
The process begins with bladder filling, where the bladder wall stretches as urine accumulates. This stretching activates the urine storage reflex, mediated by the sacral spinal segments and the pontine storage center. Efferent sympathetic impulses stimulate the detrusor muscle to relax and the internal urethral sphincter to contract, facilitating...
The process begins with bladder filling, where the bladder wall stretches as urine accumulates. This stretching activates the urine storage reflex, mediated by the sacral spinal segments and the pontine storage center. Efferent sympathetic impulses stimulate the detrusor muscle to relax and the internal urethral sphincter to contract, facilitating...
678
Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations
13
Renal calculi, commonly termed kidney stones, are crystalline solid masses that form in the kidneys but can occur at any point within the urinary system, encompassing the kidneys, ureters, bladder, and urethra.The pathophysiology of renal stones involves several key factors: supersaturation of the urine with stone-forming constituents, changes in urine pH, a decrease in urine volume, and the presence of substances that promote or inhibit stone formation.Supersaturation of Urine: This is the...
13
Nursing Assessment of the Genitourinary System II: Inspection and Palpation
127
The nursing assessment of the genitourinary (GU) system involves a systematic inspection and palpation to identify abnormalities in the kidneys, bladder, and surrounding structures.InspectionMouth: Inspect for signs of kidney dysfunction, such as stomatitis (inflammation of the mouth) and ammonia breath, which may occur in advanced kidney disease due to the buildup of urea, breaking down into ammonia.Skin: Check for pallor, which could indicate anemia caused by kidney disease. Look for...
127
Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care
14
A healthcare provider can diagnose a urinary tract infection (UTI) through several methods:Medical History and Symptoms: The provider will take a detailed medical history and ask about symptoms such as frequent urination, burning sensation during urination, and lower abdominal pain.Urinalysis: A clean-catch urine sample is collected in a sterile container and tested for the presence of bacteria, white blood cells (leukocytes), nitrites, blood, and protein. The presence of leukocytes and...
14


