在每天使用GnRH激动剂进行子宫内膜制备后的活产率与存储GnRH激动剂相比
Ulas Fidan1, Mustafa Ozturk1, Temel Ceyhan1
1Health Science University Gulhane Medical Faculty, IVF Center, Ankara, Turkey.
概括
仓库性腺激素释放激素激动剂 (GnRHa) 是冷胚胎转移周期中人工子宫内膜制备的经济有效和方便的选择. 仓库和每日GnRHa方案都显示了类似的活产率,使得仓库GnRHa成为一个切实可行的选择.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 在体外受精 (IVF)
- 遗传学 遗传学 是一个
背景情况:
- 腺激素释放激素激动剂 (GnRHa) 在试管婴儿中对排卵诱导和人工子宫内膜制备至关重要.
- 冷解胚胎转移到人工制备的子宫内膜 (FET-APE) 通常使用GnRHa,每天服用或作为储存注射.
- 这些GnRHa给药方法对子宫内膜制备的比较疗效尚不清楚.
研究的目的:
- 为了比较储存GnRHa与每日GnRHa注射在FET-APE循环中的人工子宫内膜制备的有效性.
- 为了评估两个GnRHa方案之间的Beta人类胆管性淋巴腺素 (BHCG) 阳性和活产率 (LBR).
主要方法:
- 在2018-2021年期间,对72名接受第5天PGT-A胚胎移植的患者进行了回顾性研究.
- 患者被分为两组:第一组 (n=36) 接受了储存GnRHa,第二组 (n=36) 每天接受GnRHa注射以进行子宫内膜制备.
- 所有胚胎都经历了基因查,并转移了单胞胎胚胎.
主要成果:
- 储存GNRHa的BHCG阳性率为75%,每日注射的BHCG阳性率为80.6%.
- 存储GnRHa的活产率为58.3%,每日注射的活产率为63.9%.
- 对于任何结果,两组之间没有观察到统计学上显著的差异.
结论:
- 在FET-APE中,Depot GnRHa是人工子宫内膜制剂的可行和有效替代品.
- 与每日注射相比,Depot配方提供了一个更方便和潜在的成本效益更高的选择.
- 临床环境,特别是繁忙的环境,可以从仓库GnRHa管理的实际优势中受益.
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