相关实验视频

Updated: Jul 12, 2025

Identifying PD-1/PD-L1 Inhibitors with Surface Plasmon Resonance Technology

Identifying PD-1/PD-L1 Inhibitors with Surface Plasmon Resonance Technology

Published on: May 2, 2025

网站选择性功能化PD-1突变因子对抗癌细胞的模块化免疫活动

Silvia Fallarini¹, Linda Cerofolini^2,3, Maria Salobehaj^2,3

¹Department of Pharmaceutical Sciences, DSF, University of Piemonte Orientale, Largo Donegani 2, Novara (NO) 28100, Italy.

Biomacromolecules

|October 30, 2023

概括

研究人员开发了一种新的PD-1突变,以向表达PD-L1的癌细胞,提供一种新的非抗体治疗方法. 这项创新扩大了目前癌症免疫疗法之外的选择,例如PD-1/PD-L1阻断抗体.

科学领域:

免疫学免疫学免疫学
在瘤学瘤学.
生物化学生物化学

背景情况:

针对PD-1/PD-L1通路的免疫检查点抑制剂是已知的癌症疗法.
阻断PD-1/PD-L1相互作用的抗体恢复了抗癌免疫活性.
高亲和度PD-1外域突变为针对PD-L1.1的抗体提供了一个新的替代方案.

研究的目的:

为了引入一种新的PD-1突变,作为一种非抗体治疗剂.
扩大化学空间以准过度表达PD-L1.1的癌细胞.
为未来的应用展示选址标记的潜力.

主要方法:

工程和特征的高亲和度PD-1ectodomain突变.
使用聚乙烯甘醇 (PEG) 部分和免疫刺激碳水化合物作为位点选择性标签.
评估突变体在准PD-L1表达癌细胞方面的有效性.

主要成果:

开发的PD-1突变体对PD-L1.1具有很高的亲和力.
突变者扩大了治疗场景,超越了抗体和小分子.
选择性PEGylation和碳水化合物结合表明了先进应用的概念验证.

结论:

这种新型PD-1突变代表了PD-L1表达性癌症的有前途的新疗法.
这种方法扩大了癌症免疫治疗中的治疗策略.
标记策略为开发下一代向癌症治疗提供了基础.

更多相关视频

Tailoring In Vivo Cytotoxicity Assays to Study Immunodominance in Tumor-specific CD8+ T Cell Responses

Tailoring In Vivo Cytotoxicity Assays to Study Immunodominance in Tumor-specific CD8+ T Cell Responses

Published on: May 6, 2019

Author Spotlight: Magnetic Fluorescent Bead-Based Dual-Reporter Flow Analysis of PDL1-Vaxx Peptide Vaccine-Induced Antibody Blockade of the PD-1/PD-L1 Interaction

Author Spotlight: Magnetic Fluorescent Bead-Based Dual-Reporter Flow Analysis of PDL1-Vaxx Peptide Vaccine-Induced Antibody Blockade of the PD-1/PD-L1 Interaction

Published on: July 7, 2023

相关概念视频

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.