腔肺辅助器件设计的解剖学合规性:在Fontan患者中进行虚拟适应研究
Barbara Karner1,2, Andreas Escher1, Therese Schorn1
1From the Department of Cardiac Surgery, Medical University of Vienna, Vienna, Austria.
概括
一个单个出口腔肺辅助装置 (CPAD) 在Fontan患者身上显示出比双出口设计更好的解剖适应性. 这一发现对于开发各种单心室解剖学的机械循环支持 (MCS) 至关重要.
科学领域:
- 生物医学工程 生物医学工程
- 心血管外科心血管外科
- 儿童心脏病学 儿童心脏病学
背景情况:
- 机械循环支持 (MCS) 设备正在为Fontan人口开发.
- 患者解剖学的异质性对设备设计和植入提出了重大挑战.
研究的目的:
- 在临床前评估拟议的肺辅助器件 (CPAD) 设计的解剖学合规性.
- 为了比较双出口和单出口CPAD设计在Fontan患者队列中的可行性.
主要方法:
- 将双出口和单出口CPAD设计虚拟植入到10名Fontan患者的CT成像数据中.
- 评估解剖学相容性,包括靠近重要结构和移植结构.
- 根据患者特定的解剖学来评估设备的适合性.
主要成果:
- 双出口CPAD设计仅在10分之一的患者 (10%) 中可行,观察到气管或大动脉交叉和移植扭曲等问题.
- 一个单端CPAD设计显示了增强的适应性,在10名患者中有9名 (90%) 获得了成功的设备拟合.
- 单个出口设计更有效地适应了个体解剖学变异.
结论:
- 单个出口的CPAD设计提供了优越的解剖兼容性,与Fontan患者的双出口设计相比.
- 这种设计可以为更广泛的失败的Fontan患者提供体内空腔肺机械循环支持.
- 进一步开发单端CPAD是有必要的,以满足异构的Fontan人口的需求.
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