慢波睡眠损失与事件痴呆症之间的关联
Jayandra J Himali1,2,3,4,5, Andree-Ann Baril1,6,7, Marina G Cavuoto8
1Framingham Heart Study, Framingham, Massachusetts.
JAMA neurology
|October 30, 2023
概括
慢波睡眠 (SWS) 的下降与老年人痴呆症风险增加有关. 减少SWS损失可能是预防痴呆症的关键策略.
科学领域:
- 神经科学是一个神经科学.
- 睡眠医学 睡眠医学
- 老年学是一门学科.
背景情况:
- 慢波睡眠 (SWS) 对大脑健康至关重要,有助于清除与阿尔茨海默病有关的蛋白质.
- 在痴呆症的发展中SWS下降的确切作用仍然不清楚.
- 老龄化通常与SWS减少有关,但其与痴呆风险的直接联系需要进一步调查.
研究的目的:
- 调查与年龄相关的SWS损失与患痴呆症的风险之间的关联.
- 探索阿尔茨海默病的遗传风险或海马体积减少是否影响SWS下降.
- 确定SWS损失是否是发生痴呆症的独立风险因素.
主要方法:
- 一项前性队列研究,利用来自弗雷明汉心脏研究的数据.
- 包括346名年龄在60岁以上的参与者,两次夜间多睡眠学 (PSG) 研究大约隔5.2年.
- 痴呆风险在17年的随访中进行了裁决,统计分析是在2020年1月至2023年8月之间进行的.
主要成果:
- 老龄化与SWS百分比的每年显著下降有关 (平均变化为-0.6%).
- 在17年内,每年1%的SWS下降都与患痴呆症风险增加27%有关.
- SWS损失是由APOE ε4等位基因 (阿尔茨海默病遗传风险) 的存在加速的,但不是海马体积.
结论:
- 慢波睡眠的百分比自然会随着年龄的增长而下降,并且由于阿尔茨海默病的遗传风险进一步降低.
- 减少SWS与发生痴呆症的风险增加显著相关.
- 睡眠质量损失成为痴呆症的潜在可修改风险因素,突出显示睡眠质量对大脑健康的重要性.
相关概念视频
Dementia
120
Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
The progression of dementia is generally gradual....
120
Insufficient Sleep and Sleep Deprivation
149
Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
Sleep deprivation is a more severe form of sleep loss...
Sleep deprivation is a more severe form of sleep loss...
149
Substance Use Disorders Affecting Sleep
174
Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...
Understanding the concepts of physical dependence,...
174
Sleep Apnea
164
Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...
The condition is more prevalent among...
164
Sleep-Wake Cycles
1.4K
Sleep is an essential physiological process vital to maintaining overall well-being. The reticular activating system (RAS), a network of neurons in the brainstem, regulates wakefulness and sleep. While it may seem passive, sleep consists of distinct cycles, each with its unique characteristics and functions. Two key sleep phases are non-rapid eye movement (NREM) and rapid eye movement (REM).
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
1.4K
Alzheimer's Disease: Overview
500
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
500


