由背侧前额叶皮层对前庭输入的自上而下的控制
Brendan McCarthy1,2, Sudipta Datta1,2, Gianni Sesa-Ashton1
1Baker Heart and Diabetes Institute, Melbourne, VIC, Australia.
Experimental brain research
|October 30, 2023
概括
脊侧前额皮层 (dlPFC) 的电刺激可以减少前庭感觉,如摇和恶心. 这表明dlPFC对前庭处理进行了自上而下的控制,为运动恶心提供了潜在的治疗方法.
科学领域:
- 神经科学是一个神经科学.
- 垂体系统 垂体系统 垂体系统
- 神经刺激是一种神经刺激.
背景情况:
- 前体器官提供重要的空间和引力信息.
- 低频的阴侧状状前庭刺激 (sGVS) 可以诱导摇摆和恶心的感觉.
- 岛内皮质是前庭皮质的一部分,从背侧前额皮质 (dlPFC) 接收输入.
研究的目的:
- 调查dlPFC的电刺激是否可以调节前庭输入.
- 测试dlPFC对前庭处理的自上而下的控制假设.
主要方法:
- 参与者接受了鼻状电刺激 (±2 mA,0.08 Hz) 通过状过程 (sGVS),dlPFC (F4或F3),或同时 (sGVS + dlPFC).
- 23名参与者接受了右侧dlPFC刺激,13名参与者接受了左侧dlPFC刺激.
- 记录了摇摆和恶心的感觉.
主要成果:
- sGVS诱导了参与者的摇摆感知和恶心.
- 单靠dlPFC刺激并没有引起这些感觉.
- 同时的sGVS和dlPFC刺激几乎完全消除了前庭感知和恶心.
结论:
- dlPFC对前庭输入进行了自上而下的控制.
- dlPFC刺激可能提供了一种新的治疗方法,用于管理与前体乱相关的恶心.
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