相关实验视频

Updated: Jul 12, 2025

Knee Arthrocentesis in Adults

Knee Arthrocentesis in Adults

Published on: February 25, 2022

在膝关节关节整形手术中具有骨内区域预防的突液中较高的塞法索林度:一种随机对照试验

Jingyu Zhang¹, Guangxiang Chen¹, Xiao Yu¹

¹Department of Orthopaedics, Suzhou Municipal Hospital, The Affiliated Hospital of Nanjing Medical University, No 26, Daoqian Street, Suzhou, 215000, Jiangsu, People's Republic of China.

Archives of orthopaedic and trauma surgery

|October 30, 2023

概括

与静脉输送相比,区域性骨内塞法林的使用显著增加了突液度. 这种方法提供了优越的抗生素组织水平,以预防周围假肢关节感染.

科学领域:

整形外科手术整形外科手术
药理学药理学是指药理学的学科.
传染性疾病传染性疾病

背景情况:

预防性抗生素对于预防周围假肢关节感染 (PJI) 至关重要.
系统性抗生素的输送可能会导致组织度不足以对抗耐药细菌,如凝结酶负型葡萄球菌.
骨内 (IO) 区域管理显然会提高抗生素组织水平,而不是系统静脉 (IV) 途径,但其对突液度的影响仍在调查中.

研究的目的:

为了比较区域性骨内和全身静脉注射之间的突液中塞法索林度.
为了评估两种给药途径的皮下脂肪中塞法佐林度.

主要方法:

接受初级膝关节关节整形手术的60名患者被随机分为两组:IO和IV.
在IO组接受2g的骨内塞法林通过带管后轮膨胀.
输液组在轮充气前30分钟内静脉注射2g的塞法索林. 采集了突液和皮下脂肪的样本,用于高性能液态染色学分析.

主要成果:

与IV组 (17.6 ± 3.5 微克/毫升) 相比,IO组 (391.3 ± 70.1 微克/毫升) 的阴道液塞法索林度显著更高.
在IO组 (247.9±64.9μg/g) 中,皮下脂肪塞法索林度也大大高于IV组 (11.4±1.9μg/g).

结论:

与系统性静脉注射相比,切法林的骨内区域注射在突液和皮下脂肪中达到明显更高的度.
这种通过IO路线增强的药物输送可能会改善对PJI的预防,特别是在具有挑战性的感染中.

关键词:

抗生素抗生素是一种抗生素.骨内区域管理机构膝关节关节整形手术膝关节关节整形手术周围假肢关节感染预防预防预防

更多相关视频

Novel Diagnostics in Revision Arthroplasty: Implant Sonication and Multiplex Polymerase Chain Reaction

Novel Diagnostics in Revision Arthroplasty: Implant Sonication and Multiplex Polymerase Chain Reaction

Published on: December 3, 2017

A Novel Method to Determine the Longitudinal Antibacterial Activity of Drug-Eluting Materials

A Novel Method to Determine the Longitudinal Antibacterial Activity of Drug-Eluting Materials

Published on: March 3, 2023

相关概念视频

Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia

Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia

Intravenous regional anesthesia or the Bier block technique is used to anesthetize a specific limb or extremity. It uses exsanguinated or blood-drained vessels to transport local anesthetics or LAs to the peripheral nerve trunks. Lidocaine without vasoconstrictors like epinephrine is most commonly used for this technique. Other drugs used are prilocaine, ropivacaine, and chloroprocaine. Bupivacaine is not recommended for this technique due to its high cardiac toxicity.
One of the advantages of...

Local Anesthetics: Clinical Application as Epidural Anesthesia

Local Anesthetics: Clinical Application as Epidural Anesthesia

Epidural anesthetics are administered in the fat-filled epidural space, the outermost part of the spinal canal. This technique is commonly employed for pain management and anesthesia during lower abdomen and pelvis surgeries or labor and delivery.
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...