甲状腺结节的分子测试:我们现在在哪里?
1Thyroid Diseases Unit - Division of Endocrinology, Department of Medicine, Faculty of Medical Sciences of Santa Casa of Sao Paulo, Av. Angélica, 2491 cj 104 - CEP: 01232-011, São Paulo, SP, Brazil. carolina.ferraz.endocrinologia@gmail.com.
Reviews in endocrine & metabolic disorders
|October 30, 2023
概括
分子测试改善了甲状腺结节的诊断,减少了对不确定的样本进行不必要的手术 (Bethesda III/IV). 这些测试还为甲状腺癌管理提供了预后和治疗见解.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 分子诊断学 分子诊断
背景情况:
- 不确定的甲状腺结节 (Bethesda III/IV) 占精细针吸收的25%.
- 从历史上看,大多数不确定的结节需要诊断手术,恶性瘤确认率低 (13-34%).
研究的目的:
- 审查分子测试在管理不确定的甲状腺结节中的实用性.
- 根据测试前恶性瘤风险指导分子测试的应用.
- 讨论分子标记物在甲状腺癌中的不断演变的预后和治疗作用.
主要方法:
- 评估临床,超声波和细胞学特征,以估计测试前恶性瘤风险.
- 商业上可用的分子测试对诊断准确性的评估.
- 关于在甲状腺癌中应用分子标记物的当前文献的综述.
主要成果:
- 分子测试证明了不确定的甲状腺结节的良好诊断性能和准确性.
- 这些测试可以帮助避免不必要的诊断手术.
- 分子标志物越来越多地用于预后和指导向治疗.
结论:
- 分子检测是管理不确定的甲状腺结节的一个有价值的工具.
- 关于分子测试的个性化决定可以基于测试前的风险评估.
- 分子标记在甲状腺癌的诊断,预后和治疗中起着至关重要的作用.
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