使用心脏MRI进行肺动脉硬性的表征
Michael T Cain1, Michal Schäfer2,3, Sarah Park1
1Division of Cardiothoracic Surgery, Department of Surgery, University of Colorado - Denver | Anschutz Medical Campus, Aurora, CO, USA.
The international journal of cardiovascular imaging
|October 30, 2023
概括
心脏MRI (CMR) 现在可以评估肺动脉硬度 (PAS),这是肺高血压 (PH) 的关键指标. 这种非侵入性方法显示出早期PH检测和改进风险评估的巨大潜力.
科学领域:
- 心血管成像 - 心血管成像
- 肺高血压研究 肺高血压研究
- 生物标志物发现发现
背景情况:
- 肺动脉硬度 (PAS) 是所有形式的肺高血压 (PH) 的关键标志物.
- 心脏MRI (CMR) 是评估心脏功能和肺流量的黄金标准,传统上用于PH的临床随访和研究.
- 最近的进展将侵入性和非侵入性CMR数据整合到PAS表型中,并评估其预后价值.
研究的目的:
- 审查过去二十年中CMR衍生PAS指数的演变和应用.
- 用CMR评估各种PAS评估方法的好处,局限性和病理生理相关性.
- 讨论基于CMR的PAS评估在PH监测,表型和潜在的治疗管理中的作用.
主要方法:
- 对过去20年发表的重点研究的综述,重点关注PH中的CMR和PAS.
- 分析来自CMR的不同PAS指数,比较它们的诊断和预后性能.
- 探索应用于CMR数据的机器学习策略,以加强PAS评估.
主要成果:
- 来自CMR的PAS标志物在预测PH的长期临床结果方面具有显著的潜力.
- 这些标记可以增强当前的风险评估工具,如REVEAL计算器.
- 多中心研究报告了PAS的CMR强大的诊断和预后性能,具有早期PH检测的潜力.
结论:
- 使用CMR进行PAS的非侵入性评估正在接近常规临床应用.
- 来自CMR的PAS指数为肺血管重塑和PH严重程度提供了宝贵的见解.
- 未来的目标包括利用PAS作为针对PH治疗的生物标志物.
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