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术前施用西洛多辛是否能在灵活尿路透镜检查过程中促进尿路扩张? 一个随机的临床试验
Tamer Diab1, Waleed El-Shaer2, Saad Ibrahim2
1Urology Department, Faculty of Medicine, Benha University, Benha, Qalyubiyya Governorate, Egypt. Tamer.diab@fmed.bu.edu.eg.
International urology and nephrology
|October 30, 2023
概括
在手术前使用的西洛多可显著减少尿路壁损伤,在柔性尿路透镜 (F-URS) 进行尿路接入外套放置期间. 这种药物有助于预防损伤,并改善患者在具有挑战性的石头病例中的结果.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 内分泌病学 在内分泌病学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 在柔性尿道透视术 (F-URS) 期间,尿道接入 (UAS) 的放置可能导致尿道损伤.
- 尽量减少尿路外伤对于患者的安全和手术成功至关重要.
研究的目的:
- 为了评估手术前的silodosin在促进UAS安置方面的有效性.
- 在具有挑战性的情况下,确定西洛多是否减少F-URS期间的尿路损伤.
主要方法:
- 一项前性随机临床试验,涉及147名患上尿路上部或脏结石的非造骨患者.
- 患者在F-URS之前每天接受8毫克西洛多辛一周或安慰剂.
- 在UAS插入后评估了尿路壁损伤.
主要成果:
- 尿道壁损伤发生在西洛多组的33.3%,而安慰剂组的59.7% (P < 0.001).
- 西洛多辛,手术时间和患者年龄是尿道壁损伤的重要风险因素.
- 在两组之间观察到尿管壁损伤的程度的统计学上显著差异.
结论:
- 在F-URS期间,手术前施用西洛多辛有效地预防了尿路壁的显著损伤.
- 西洛多促进了UAS的安置,并减少了手术后的不适.
- 这种方法有利于管理具有挑战性的尿路结石病例.
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