人类乳头瘤病毒阴性头支状细胞癌的分子分类:基于细胞周期的分类器和预后签名
Hao Gu1, Tingxuan Li1, Narasimha M Beeraka2,3,4
1Department of Radiation Oncology & Cancer Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
PloS one
|October 30, 2023
概括
这项研究根据细胞周期基因将人乳头瘤病毒 (HPV) 阴性头角状细胞癌 (HNSCC) 分类为两种亚型. 这些亚型显示出不同的瘤微环境,预后和治疗反应,有助于个性化治疗.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 基因组学就是基因组学.
背景情况:
- 人类乳头瘤病毒 (HPV) 阴性头角状细胞癌 (HNSCCs) 的分子分类需要进一步细化.
- 基因表达概况显示,在HPV阴性HNSCC中,细胞循环途径发生了显著的改变.
研究的目的:
- 使用细胞周期相关基因对HPV阴性HNSCC进行分类.
- 确定分子亚型与瘤进展,临床结果和治疗反应相关联.
主要方法:
- 来自740个HPV阴性HNSCC样本的RNA测序数据的无监督共识聚类.
- 来自癌症基因组图谱 (TCGA),临床蛋白质瘤分析联盟 (CPTAC) 和基因表达综合 (GEO) 数据库的数据分析.
- 分子亚型与临床参数和治疗疗效的相关性分析.
主要成果:
- 根据细胞周期基因表达,确定了两种不同的HPV阴性HNSCC亚型 (C1和C2).
- 亚型C1表现出低细胞周期活性,"热"瘤微环境,以及更好的预后,具有更高的免疫疗法和向治疗反应率.
- 亚型C2表现出高细胞周期活性,"冷"的瘤微环境,更糟糕的预后和较低的治疗响应率.
结论:
- 细胞周期基因表达模式可以有效地将HPV阴性HNSCC分为预后和治疗上不同的亚型.
- 这种分类为推动HPV阴性HNSCCs的分子机制提供了洞察力.
- 这些发现可能会为HPV阴性HNSCCs患者提供个性化治疗策略.
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