自粘性,生物相容性,可穿戴的微流体与可擦拭的液体金属等离子热点,用于检测汗水中的葡萄糖
Qingwei Yuan1,2, Hui Fang2, Xiuru Wu1,2
1Institute for Advanced Study, Shenzhen University, Shenzhen 518060, China.
ACS applied materials & interfaces
|October 30, 2023
概括
一个新的可穿戴微流体芯片使用可删除的等离子热点和表面增强的拉曼光谱学精确检测出汗中的葡萄糖. 这种非侵入性设备提供了一种灵敏,可重复的方法,用于监测可穿戴健康技术应用中的葡萄糖水平.
科学领域:
- 生物医学工程 生物医学工程
- 分析化学 分析化学
- 材料科学 材料科学 材料科学
背景情况:
- 汗水分析提供了对生理条件的非侵入性窗口,葡萄糖水平与血糖相关,并表明糖尿病人的健康状况.
- 现有的汗水监测方法往往缺乏持续健康跟踪所需的灵敏度,可复制性或可穿戴性.
- 可穿戴生物传感器对于实时健康监测至关重要,特别是在管理糖尿病等慢性疾病时.
研究的目的:
- 开发一种自粘,可穿戴的微流体芯片,用于精确,非侵入性地检测汗水中的葡萄糖.
- 整合可擦除的液体金属等离子热点,用于增强的表面增强拉曼光谱 (SERS) 检测.
- 为了实现汗液中葡萄糖的低检测极限,适合生理监测.
主要方法:
- 制造一种粘性,可穿戴的微流体芯片,由改性聚甲基氧 (PDMS) 制成,用于收集,输送和储存汗水.
- 在微流体通道内的液体金属上生成并可删除的基于银纳米结构的等离子热点.
- 用4-mercaptophenylboronic酸修改SERS基底,以提高葡萄糖检测灵敏度.
主要成果:
- 开发的芯片证明了符合皮肤接触和有效的汗水处理.
- 可删除和可重复的等离子热点已成功集成并用于SERS.
- 在1 ng/L时达到高灵敏度的葡萄糖检测极限,明显低于生理性汗液葡萄糖度.
- 传感器表现出柔软,可伸缩和无毒的特性.
结论:
- 可穿戴的微流体芯片带有可删除的等离子热点,为准确而敏感的汗水葡萄糖监测提供了一个有前途的平台.
- 这项技术推进了非侵入性诊断和可穿戴健康感应能力,特别是用于糖尿病管理.
- 热点的可删除性质确保了设备的可重复使用性和可重复的测量,从而增强了实际应用.
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