长期使用抗血管内膜生长因子疗法治疗新血管与年龄相关的黄斑退化
Tedi Begaj1,2, Daeun Jeong2, Jong G Park1,2
1Associated Retinal Consultants/Beaumont Health, Royal Oak, Michigan.
Retina (Philadelphia, Pa.)
|October 30, 2023
概括
长期抗血管内皮生长因子治疗新血管与年龄相关的黄斑变性 (nAMD) 在一些患者中显示持续视力. 虽然最初的视力敏度会影响长期结果,但治疗仍然有效,并发症风险低.
科学领域:
- 眼科医生 眼科 眼科
- 视网膜疾病 视网膜疾病
- 医疗治疗 医疗治疗
背景情况:
- 关键试验证实了抗血管内皮生长因子 (anti-VEGF) 在新血管与年龄相关的黄斑变性 (nAMD) 中的疗效.
- 对于nAMD的长期 (>5年) 治疗结果,临床数据有限.
研究的目的:
- 评估nAMD患者抗VEGF治疗的长期 (>5年) 治疗结果.
- 为了评估视力敏度的变化,药物耐用性和长时间的nAMD队列中的安全概况.
主要方法:
- 对接受超过40次抗VEGF注射并被跟踪5年或更长时间的nAMD患者的回顾性分析.
- 收集的数据包括斯内伦校正视敏度 (SCVA),初始药物选择和治疗间隔.
- 评估了内眼炎的发生率和亚黄斑出血的结果.
主要成果:
- 88名患者 (162只眼睛) 平均随访时间为7.6年,平均每只眼睛注射69次.
- 与基线相比,在多个注射点观察到SCVA的统计学显著改善.
- 最初SCVA为20/40或更好的患者保持视力更长时间,而视力较差的患者 (≤20/50) 显示出最初的改善,然后减弱.
- 记录了较低的内膜炎 (0.05%) 率,七只眼睛经历了黄斑下出血.
结论:
- 患有nAMD的患者平均每年接受8次抗VEGF注射,持续约8年.
- 良好的初始视力预测持续的视力,而初始视力较差的结果是随着时间的推移逐渐减少.
- 大多数患者继续服用他们最初的抗VEGF药物,内甲状腺炎的发病率很低.
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