内分泌粘素产生汗腺癌和原发性皮肤粘性癌:一个案例系列
Solomiya Grushchak1, Thomas Barlow1, Beth Palla1
1Scripps Bighorn Mohs Surgery and Dermatology Center, La Jolla, California.
Cutis
|October 30, 2023
概括
内分泌粘素产生汗腺癌 (EMPSGC) 和初级皮肤粘膜癌 (PCMC) 是罕见的皮肤癌. 这些瘤可能代表单一的疾病连续性,EMPSGC进展到侵袭性PCMC,需要手术治疗.
科学领域:
- 皮肤病学 皮肤病学
- 在瘤学瘤学.
- 病理学 病理学 病理学
背景情况:
- 内分泌粘素产生的汗腺癌 (EMPSGC) 和原发性皮肤粘膜癌 (PCMC) 是罕见的,低度的瘤.
- 两者都被认为起源于分泌腺,并具有显著的组织学相似之处.
- 假设它们存在于单一的基因病学连续体上,EMPSGC可能会发展为侵入性PCMC.
研究的目的:
- 呈现EMPSGC和PCMC的临床和组织病理特征.
- 审查这些罕见的皮肤瘤的差异诊断.
- 讨论目前EMPSGC和PCMC的治疗方式.
主要方法:
- 2个EMPSGC和3个PCMC案件的案例系列呈现.
- 对临床和组织病理学发现的审查.
- 对差异诊断和治疗策略的文献综述.
主要成果:
- EMPSGC和PCMC具有重叠的临床和组织学特征.
- 管理需要转移性工作和外科切除 (WLE或MMS).
- 不同诊断包括其他粘膜性皮肤病变.
结论:
- EMPSGC和PCMC可能代表同一疾病过程的各个阶段.
- 适当的手术管理对于有利的结果至关重要.
- 对连续性和最佳治疗的进一步研究是有必要的.
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