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乳腺癌化疗期间运动对长期心血管毒性的影响
Willeke R Naaktgeboren1,2, Martijn M Stuiver1,3,4, Wim H van Harten1,5,6
1Psychosocial Research and Epidemiology, Antoni van Leeuwenhoek Netherlands Cancer Institute, Amsterdam, The Netherlands.
Open heart
|October 30, 2023
概括
乳腺癌化疗期间的运动可能会改善长期的心脏结构,但没有观察到功能性改善. 对于癌症幸存者来说,对心脏保护策略的进一步研究,包括运动,是有必要的.
科学领域:
- 心脏病学 心脏病学
- 在瘤学瘤学.
- 运动科学 运动科学
背景情况:
- 关于化疗期间运动的心脏保护作用的临床数据有限.
- 动物研究表明,运动可以在癌症治疗期间保护心脏.
研究的目的:
- 评估化疗期间运动对乳腺癌幸存者的心血管毒性的长期影响.
- 为了评估心脏成像参数,健康状况和治疗几年后的身体活动水平.
主要方法:
- 两项随机试验的随访,比较化疗期间的运动与非运动对照.
- 心脏成像 (原生T1,细胞外体积分数 (ECV),LVEF,GLS) 在治疗后8.5年进行评估.
- 还测量了心肺健康和身体活动水平.
主要成果:
- 包括185名乳腺癌幸存者 (99%的 antracyclines,18%的 trastuzumab) 在内.
- 与对照组相比,运动组在统计学上显著地显示出较低的原生T1.
- 没有发现运动对ECV,LVEF或GLS有显著影响.
- 化疗期间更高的体力活动与更好的原生T1和ECV相关.
结论:
- 化疗期间的运动与长期改善的心脏结构 (原生T1) 相关,但在乳腺癌幸存者中没有功能.
- 观察到心脏功能障碍的高患病率,突出显示了心脏保护措施的必要性.
- 建议对替代运动方案进行进一步的研究.
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