在早产单子与双胞胎怀孕中,用于剖腹产的静脉内高压罗皮瓦卡因的比较剂量反应研究
Miao Zhu1, Ju-Jun Liu1, Yan-Ping Shen1
1Department of Anesthesiology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Regional anesthesia and pain medicine
|October 30, 2023
概括
在剖腹产期间,对内高压罗皮瓦卡因的剂量要求在早产双胞胎和单胎中是相似的. 这项研究发现,双胞胎和单胞胎怀孕在相同妊娠年龄之间的罗皮瓦卡因有效剂量没有显著差异.
科学领域:
- 麻醉学 麻醉学
- 产科 产科 产科 产科 产科
- 药理学 药理学是指药理学的学科.
背景情况:
- 之前的研究表明,类似的内高压罗皮瓦卡因剂量适用于单胎婴儿和早产双胞胎.
- 在之前的研究中,潜在的混因素包括妊娠年龄和双胞胎怀孕特征的变化.
研究的目的:
- 为了确定和比较高压罗皮瓦卡因对早产双胞胎的内剂量要求,与同等妊娠年龄的单双双胞胎相比.
- 在这些不同的产科人群中确定罗皮瓦卡因的剂量反应关系.
主要方法:
- 一项随机,双盲,剂量反应研究,涉及150名接受剖腹产的患者 (75名早产单子,75名早产双胞胎).
- 患者通过结合脊柱-外皮麻醉接受了高压罗皮瓦卡因 (10,12,14,16或18毫克) 的五剂之一.
- 实验室回归分析用于计算中位有效剂量 (ED50) 和90%的患者有效剂量 (ED90),并评估相对功效.
主要成果:
- 对于早产单子,ED50为9.9毫克 (95% CI 7.2至11.5),ED90为16.8毫克 (95% CI 14.5至22.9).
- 对于早产的双胞胎,ED50为9.2毫克 (95%CI为6.4至10.8),ED90为15.6毫克 (95%CI为13.6至20.6).
- 双胞胎和单胞胎之间的相对强度 (ED50比率) 为0.933 (95% CI为0.72至1.15),表明没有显著差异.
结论:
- 在早产期的剖腹产中,内高压罗皮瓦卡因剂量要求在双胞胎和单胎怀孕之间是可比的.
- 怀孕年龄似乎是罗皮瓦卡因剂量的一个更重要的决定因素,而不是怀孕是单独的还是双胞胎的.
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