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在早期多发性硬化症中,光学辐射病变与视网膜和脑缩的相互作用

Ting-Yi Lin^1,2,3, Claudia Chien^1,2,3,4, Joseph Kuchling^1,2,3,5

¹Experimental and Clinical Research Center, a cooperation between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and the Charité - Universitätsmedizin Berlin, Berlin, Germany.

Annals of clinical and translational neurology

|October 30, 2023

概括

在早期多发性硬化症 (MS) 患者中,黄斑结节细胞内层 (GCIPL) 的更快的稀薄与光学辐射损伤活动增加和大脑缩有关.

科学领域:

神经科学是一个神经科学.
眼科医生眼科眼科
放射学放射学是一门学科.

背景情况:

逆行性跨突触神经轴突退变是多发性硬化症 (MS) 中亚临床视网膜损伤的关键因素.
了解光学辐射 (OR) 病变与视网膜神经退行之间的联系对于早期的MS治疗至关重要.

研究的目的:

评估光学辐射 (OR) 损伤活动与视网膜神经轴损伤之间的纵向关联.
评估OR病变活性在临床隔离综合征和早期MS (pweMS) 患者视网膜和大脑缩之间的相关性中的作用.

主要方法:

来自柏林CIS队列的85个pweMS的回顾性选.
3T MRI用于OR损伤体积和大脑缩;OCT用于视网膜层厚度.
连续性OCT和MRI的中位数随访时间为2.9年;排除之前有视神经炎的眼睛.

主要成果:

黄斑结节细胞内状层 (GCIPL) 稀薄在增加OR病变体积的pweMS中更为明显.
GCIPL稀释与OR病变体积增加和大脑缩显著相关.
无论OR病变的增加,GCIPL变化和大脑缩之间的相关性都是一致的.

结论:

较快的GCIPL稀释率与pweMS中OR病变负载的增加有关.
在MS中,GCIPL作为后视通路病理和全球大脑神经退行症的敏感生物标志物.

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