在巴西队列中,早期成年期的吸烟暴露轨迹和肺功能
P Weber1,2, A M B Menezes1, H Gonçalves1
1Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil.
Pulmonology
|October 30, 2023
概括
产妇在子宫内吸烟会影响后来的肺功能. 在青春期和成年期继续吸烟会显著降低肺功能,增加呼吸道症状.
科学领域:
- 呼吸系统医学 呼吸系统医学
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 吸烟轨迹复杂,它们对肺功能和呼吸系统健康的长期影响需要进一步研究.
- 了解早期生命暴露和持续吸烟模式的影响对于公共卫生干预至关重要.
研究的目的:
- 分析从怀孕到成年早期的吸烟轨迹.
- 在22岁时确定吸烟模式与肺功能 (PF) 和呼吸系统症状之间的关联.
主要方法:
- 一项基于人口的队列研究,涉及3350人.
- 螺旋测量用于评估肺功能,包括FEV1,FVC,FEF25-75%,FEV1/FVC和FEF25-75%/FVC.
- 基于组的轨迹建模应用于在多个时间点 (产前,15岁,18岁和22岁) 收集的吸烟数据.
主要成果:
- 确定了四种吸烟轨迹:没有暴露 (NE),妊娠期 (GE),妊娠期和成年期 (GAE) 和持续 (CE).
- 与NE相比,CE和GAE轨迹都与FEV1/FVC和FEF25-75%/FVC比率显著降低有关.
- GAE与较低的FEV1和FEF25-75%值有关. 持续吸烟 (每天≥10支烟) 也显示了减少PF的措施.
- 在CE的轨迹显示出更高的喘息和咳的几率.
结论:
- 在子宫内暴露于母亲吸烟对后来的肺功能有不利影响.
- 在整个青春期和成年早期持续吸烟行为是显著的肺功能下降和呼吸系统症状的发展的关键决定因素.
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