在使用免疫疗法治疗晚期前列腺癌方面存在种族差异
Ali Mouzannar1, Jessica Delgado1, Deukwoo Kwon2
1Department of Urology, USA.
Journal of the National Medical Association
|October 30, 2023
概括
在转移性割抵抗性前列腺癌 (mCRPC) 中,免疫治疗的使用在2010年后增加,但主要受益于白人患者. 黑人患者的免疫疗法利用率下降,突出了获得新疗法的差异.
科学领域:
- 在瘤学瘤学.
- 健康差异 在健康上的差异
- 癌症治疗方法 癌症治疗方法
背景情况:
- 转移性割抵抗性前列腺癌 (mCRPC) 是前列腺癌的晚期阶段.
- 免疫疗法代表了mCRPC的新型治疗方法.
- 了解治疗利用差异对于公平的癌症护理至关重要.
研究的目的:
- 调查黑人mCRPC患者免疫治疗利用的差异.
- 为了比较免疫疗法和化疗的使用趋势在种族群体之间的mCRPC.
主要方法:
- 国家癌症数据库 (2010-2015年) 对mCRPC患者的分析.
- 检查免疫疗法和化疗使用的年度趋势.
- 多变量分析以确定治疗类型的预测因子.
主要成果:
- 从2010年开始,mCRPC的整体免疫疗法使用量增加,在2014年达到顶峰.
- 增加免疫疗法利用率主要在白人患者中观察到.
- 在研究期间,黑人患者的免疫疗法利用率下降.
结论:
- 美国食品和药物管理局 (FDA) 对西普卢塞尔-T的批准与免疫疗法使用的增加相吻合,主要是在白色mCRPC患者身上.
- 黑人mCRPC患者没有增加使用新型免疫疗法药物.
- 需要进一步的研究,以解决在mCRPC中少数群体获得新型治疗的障碍.
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