长期心血管事件,移植失败和移植接受者的死亡率
Charlotte Andersson1, Ditte Hansen2, Søren Schwartz Sørensen3
1Cardiovascular Division, Brigham & Women's hospital, Harvard Medical School, Boston, MA, USA; Department of Cardiology, Herlev and Gentofte Hospital, Gentofte, Denmark.
European journal of internal medicine
|October 30, 2023
概括
与普通人群相比,接受移植的人面临心血管事件和衰竭的风险明显更高. 加强心血管预防策略对于改善这些患者的长期结果至关重要.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 心脏病学 心脏病学
- 移植科学 移植科学
背景情况:
- 移植接受者 (KTRs) 患有心血管事件的风险增加.
- 对KTRs的当代风险数据有限.
- 这项研究量化了KTRs的心血管疾病和功能衰竭风险.
研究的目的:
- 估计首次脏移植接受者心血管疾病和功能衰竭的1年和5年的风险.
- 将这些风险与年龄和性别匹配的对照进行比较.
- 为制定更好的预防策略提供信息. KTRs.
主要方法:
- 利用丹麦全国范围的行政数据库对一组首次脏移植接受者 (2005-2018) 进行了分析.
- 包括 1:10 的年龄和性别匹配对照的比率.
- 心血管事件,功能衰竭 (透析/再移植) 和死亡率的计算累积发病率.
主要成果:
- 与对照组相比,KTRs显示心肌梗塞,中风或心力衰竭的1年风险 (2.6%与0.5%) 和5年风险 (8.3%与2.6%) 显著增加.
- 在KTR中,累积5年死亡率明显高于KTR (10.3%对3.0%).
- 1年和5年的透析或再移植的累积发病率分别为6.1%和16.3%.
结论:
- 接受脏移植的接受者经历了心血管疾病,末期脏疾病和死亡率的长期风险.
- 尽管有当代的医疗管理,这些风险仍然存在.
- 改善心血管预防策略对于更好的KTR预后至关重要.
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