新兴的方法可以诱导对治疗性蛋白质的免疫耐受性
Justine C Noel1, Daniel Lagassé1, Basil Golding2
1Division of Hemostasis, Office of Plasma Protein Therapeutics, Center for Biologics Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, USA.
Trends in pharmacological sciences
|October 30, 2023
概括
开发向免疫疗法可以克服治疗蛋白质免疫性所面临的挑战. 新的策略旨在专门减少免疫反应,提高治疗的安全性和有效性.
科学领域:
- 生物技术是生物技术.
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 免疫性对治疗性蛋白质的安全性和有效性构成重大挑战.
- 目前的临床免疫耐受性策略往往是低效的,昂贵的,并依赖于广泛的免疫抑制,增加感染风险.
研究的目的:
- 审查用于诱导对治疗蛋白质的特定免疫耐受性的新兴技术.
- 讨论新的耐受性诱导方法的潜在和转化障碍.
主要方法:
- 对先进技术的最新原则证明研究的审查.
- 专注于基于纳米粒子的传递,细胞向/耗尽,细胞工程,基因治疗和基因编辑.
主要成果:
- 新兴技术在促进对治疗性蛋白质的特定免疫耐受性方面显示出前景.
- 这些新的方法为全球免疫抑制提供了潜在的替代方案.
结论:
- 基因编辑和纳米粒子输送等先进技术具有安全有效的治疗蛋白质使用的潜力.
- 克服转化障碍对于临床实施这些新型耐受性策略至关重要.
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