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具有致病潜力的真菌杂交的起源来自温暖的海水环境
Valentina Del Olmo1,2, Verónica Mixão1,2,3, Rashmi Fotedar4
1Life Sciences Department. Barcelona Supercomputing Center (BSC), Jordi Girona, 29, 08034, Barcelona, Spain.
Nature communications
|October 31, 2023
概括
在海洋生态系统中发现了环境酵母 Candida orthopsilosis 杂交物,揭示了缺失的父母血统. 这些杂交物表现出病原性潜力,表明它们起源于海洋,并适应宿主感染.
科学领域:
- 微生物学 微生物学
- 基因组学就是基因组学.
- 进化生物学 进化生物学
背景情况:
- 杂交是酵母体基因组变异性和适应性的关键驱动因素.
- 机会性病原体Candida orthopsilosis主要以杂交的形式存在,其中一个父母系以前未被识别.
- 在临床环境中很少发现C. orthopsilosis的亲系,可能是由于与杂交物相比的致病性较低.
研究的目的:
- 为了研究海洋生态系统中环境C. orthopsilosis菌株的基因组.
- 为了确定C. orthopsilosis遗失的父母血统.
- 探索与病变发生相关的父系和杂交物之间的表型差异.
主要方法:
- 基因组测序和环境C. orthopsilosis分离物的分析.
- 遗传学分析以确定环境和临床隔离物之间的关系.
- 在病原性条件下的表型表征.
主要成果:
- 环境C. orthopsilosis分离物主要是杂交物,与临床菌株密切相关.
- 发现了以前未知的亲系,完成了该物种的基因组概述.
- 在父系和其杂交物之间观察到显著的表型差异,特别是在与病变发生有关的条件中.
结论:
- 环境海洋生态系统是C. orthopsilosis杂交的可能来源.
- 已识别的杂交物具有内在的致病潜力.
- 环境适应可能使杂交物更容易殖民和感染哺乳动物宿主,比父母血统更有效.
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