语言网络内的fMRI波动与精神分裂症幻觉症状的严重程度相关
Chiara Spironelli1,2, Marco Marino3,4, Dante Mantini5
1Department of General Psychology, University of Padova, Padova, Italy. chiara.spironelli@unipd.it.
精神分裂症患者经历听觉口头幻觉,在右半球表现出明显的脑网络变化. 这些神经成像发现可能有助于识别精神分裂症患者对幻觉的脆弱性.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 神经成像是一种神经成像.
背景情况:
- 精神分裂症 (SZ) 是一种复杂的精神疾病,其中听觉语言幻觉 (AVH) 是一个突出的症状.
- 尽管进行了广泛的研究,但SZ中对AVH脆弱性的神经基础仍然不清楚.
- 假设改变的半球主导作用有助于自我-其他区别障碍和AVH.
研究的目的:
- 通过基于网络的fMRI方法,研究精神分裂症中幻觉脆弱性的神经相关性.
- 检查AVH和无AVH患者语言网络 (LN) 连接和波动的变化.
- 测试LN变化与自我-其他区分缺陷和AVH相关的假设.
主要方法:
- 休息状态fMRI数据使用独立组件分析 (ICA) 分析LN连接.
- 研究了三个组:有AVH的SZ患者 (AVH/D+),没有AVH的SZ患者 (AVH/D-),和健康的对照组 (HC).
- 在网络和兴趣区域 (ROI) 层面分析低频波动的分数幅度 (fALFF).
主要成果:
- 在AVH/D+患者中,特定的右半球LN节点 (岛屿,布罗卡区域同类) 的招募,与HC和AVH/D-.不同.
- fALFF分析显示了Slow-4 fALFF和妄想,以及Slow-5 fALFF和AVH/D+中的幻觉之间的相关性.
- 两组之间没有发现结构上的差异,表明功能上的变化而不是解剖上的变化.
结论:
- 在fMRI中,语言网络 (LN) 连接和波动模式可以作为精神分裂症中幻觉脆弱性的神经生理学标记.
- 右半球LN变化与精神分裂症中AVH有关,可能反映左半球缺陷.
- 研究结果支持功能网络变化的作用在SZ中AVH的表现.
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