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压力诱导的红核衰减会诱导类似焦虑的行为和淋巴结CCL5分泌

Dong-Dong Shi^1,2, Ying-Dan Zhang¹, Sen Zhang¹

¹Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Nature communications

|October 31, 2023

概括

大脑是大脑的大脑.

科学领域:

神经免疫学神经免疫学
压力神经科学神经科学
心理神经免疫学心理神经免疫学

背景情况:

人们猜测大脑活动对淋巴细胞器官免疫反应的控制,但尚未完全理解.
连接压力,淋巴细胞器官和焦虑的特定大脑区域和机制仍然难以捉摸.
了解脑淋巴结轴对于理解压力诱导的行为至关重要.

研究的目的:

为了确定在压力期间控制淋巴体器官的上游大脑区域.
阐明涉及压力诱导焦虑类行为的神经通路.
在压力期间调查CCL5在脑淋巴结沟通中的作用.

主要方法:

在压力的人类参与者和老鼠模型中分析CCL5水平.
从宫淋巴结 (CLN) 进行逆行追踪,以确定神经元群体.
使用切除和化学遗传/药物遗传操纵在老鼠中识别的神经元.
研究调制主要运动皮质对红核 (RN) 投射的影响.

主要成果:

在压力较大的个体中,CCL5水平升高,主要在CLN中产生.
红核 (RN) 中的谷氨基神经元被确定为关键参与者,其活动与CCL5水平和焦虑相关.
抑制RN神经元会加剧焦虑和CCL5表达,而激活会减少它们.
调节主要运动皮质对RN通路的影响焦虑和CCL5合成.

结论:

发现了一种涉及红核和CCL5的新型脑淋巴结轴.
淋巴细胞器官,特别是CLN,作为应激反应的内分泌器官起作用.
这个轴提供了对压力和焦虑背后的神经免疫机制的关键见解.

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