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暴露于城市纳米颗粒的低PM度作为氧化应激和炎症的来源

Francesca Costabile^1,2, Maurizio Gualtieri³, Matteo Rinaldi^2,4

¹Institute of Atmospheric Sciences and Climate - Italian National Research Council (ISAC - CNR), Via Fosso del Cavaliere, 00133 Rome, Italy.

Scientific reports

|October 31, 2023

概括

在低度下,暴露于细颗粒物 (PM2.5) 的健康影响尚不清楚. 这项研究揭示了粒子氧化潜力和大小分布,而不仅仅是PM2.5水平,驱动不良健康反应.

科学领域:

环境健康科学环境健康科学
毒理学毒理学毒理学
纳米粒子研究研究

背景情况:

微粒颗粒物 (PM2.5) 暴露与不良健康结果有关,但度-反应关系,特别是低水平,尚未完全理解.
当前的空气质量标准可能无法充分捕捉与PM2.5.5复杂性质相关的健康风险.

研究的目的:

研究PM2.5特性与低度生物反应之间的关系.
开发一种方法来评估肺部对环境空气的暴露,并尽量减少纳米颗粒采样工件.
了解氧化潜力和粒子大小分布在PM2.5引起的健康影响中的作用.

主要方法:

利用一种新的方法来模拟肺部暴露在环境空气中的情况,使用人类支气管上皮细胞 (BEAS-2B) 的空气液界面培养物.
评估了气溶的总氧化潜力 (OP2.5) 以及其在颗粒大小 (dp) 上的分布.
评估了颗粒大小依赖的冷凝槽 (CS) 和反应性物种的分布.

主要成果:

观察到非线性度-反应曲线,受OP2.5及其大小分布的相互作用的影响.
高OP2.5和纳米颗粒的城市环境气溶在PM2.5度低于5μg/m3的环境中引起了更大的促炎和氧化反应.
DTT测定表明气溶中的OP2.5较高,导致显著的生物反应.

结论:

低度的PM2.5对健康的影响受到氧化潜力和颗粒大小分布的显著影响,而不仅仅是质量度.
现有的空气质量标准可能需要改进,以包括考虑氧化潜力的分布在粒子大小上的指标.
未来的全球努力应集中在开发更全面的空气质量指标,以更好地保护公共健康.

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