循环PCSK9水平升高与败血症患者的28天死亡率有关:一项前性队列研究
Yuanlu Shu1, Ziwei Deng2, Ye Deng2
1Evidence-based Medicine and Clinical Center, The First People's Hospital of Huaihua, Huaihua, 418000, P.R. China.
BMC emergency medicine
|October 31, 2023
概括
增加的前蛋白转化酶亚素/素9 (PCSK9) 水平与败血症患者28天死亡率的增加有关. 循环中的PCSK9可以作为败血症结果的预后生物标志物.
科学领域:
- 生物化学 生化学
- 临床医学 临床医学
- 关键护理医学 关键护理医学
背景情况:
- 蛋白转化酶亚素/素9 (PCSK9) 影响脂质清除.
- PCSK9在败血症预后中的作用正在调查中.
- 了解PCSK9的影响对于败血症管理至关重要.
研究的目的:
- 为了研究PCSK9水平与败血症患者28天死亡率之间的关联.
- 为了确定PCSK9是否可以作为败血症的预后生物标志物.
主要方法:
- 对203名败血症患者进行前性队列研究.
- 根据入学水平分类为PCSK9低和PCSK9高的组.
- 时间依赖的ROC曲线和考克斯回归分析了死亡风险.
主要成果:
- 370 ng/ml的PCSK9水平被确定为一个风险切断点.
- 高PCSK9水平 (>370 ng/ml) 与28天死亡率显著增加有关 (aHR=2.56).
- PCSK9水平与C反应性蛋白正相关.
结论:
- 超过370ng/ml的基线循环PCSK9水平显著增加了败血症死亡率.
- 循环PCSK9显示潜在的预测性生物标志物为败血症预后.
- 进一步的研究可以探索PCSK9在败血症中的治疗向.
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