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通过多元组件纳米复合体对长非编码RNAASBEL和黄素联合递送的协调调节,用于同步三阴性乳腺癌治疗药物

Xuesong He¹, Fengjuan Lin², Runqing Jia¹

¹Department of Environment and Life Science, Beijing International Science and Technology, Cooperation Base of Antivirus Drug, Beijing University of Technology, Beijing, 100124, China.

Journal of nanobiotechnology

|October 31, 2023

概括

这项研究开发了用于三阴性乳腺癌 (TNBC) 治疗的新型纳米复合物. 这些复合物为致癌性lncRNA ASBEL和黄素提供抗体,有效抑制瘤生长和转移.

科学领域:

生物材料科学生物材料科学
纳米技术纳米技术
癌症治疗方法癌症治疗方法

背景情况:

长非编码RNAs (lncRNAs) 与癌症有关,其中 lncRNA ASBEL 被确定为三阴性乳腺癌 (TNBC) 的瘤基因.
向致癌性lncRNAs为TNBC治疗提供了一个治疗机会.

研究的目的:

开发一个用于协同TNBC治疗的治疗平台.
通过使用自组装纳米复合体,同时提供 lncRNA ASBEL 和黄素的对抗剂.
为了实现同步成像和治疗监测.

主要方法:

使用 Hyaluronic 酸 (HA) 和 Chitosan 化物 (CS) 制造多组件自组装的多电解质纳米复合体 (CANPs).
通过静电,结和疏水相互作用将安塔戈3 (ASBEL对抗剂) 和黄素 (Cur) 纳入CANP.
用近红外光 (NIRF) 染料 (Cy-5.5) 装饰CANP,以创建用于成像的FCANP.

主要成果:

FCANPs证明有效抑制MDA-MB-231细胞增殖,迁移和入侵,诱导显著的细胞亡.
分子分析显示了lncRNA ASBEL/BTG3轴和下游信号通路 (Bcl-2,c-Met) 的有效调节.
系统管理导致瘤组织中FCANPs和黄素的有针对性的积累.

结论:

在TNBC模型中,FCANPs有效抑制异种移植瘤生长,抑制转移,并延长生存率.
开发的治疗神经平台提供了一个有前途的方法,用于结合疗法,最小的系统毒性.
这项研究突出了纳米复合物的潜力,用于协同TNBC治疗和监测.

关键词:

库尔库明是一种黄素.在LncRNA ASBEL中.聚电解质纳米复合物中的多电解质纳米复合物自己组装的自组装.同步的超声波学.三阴性乳腺癌是三阴性乳腺癌.

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