探索使用集群分析来评估在资源较少的环境中,对重症新生儿的抗生素管理
Roberto Benoni1,2,3, Eleonora Balestri4,5, Tariqua Endrias6
1Department of Woman's and Child's Health, University of Padua, Via Giustiniani, 3, Padua, 35128, Italy. roberto.benoni90@gmail.com.
Antimicrobial resistance and infection control
|October 31, 2023
概括
埃塞俄比亚的新生儿败血症治疗揭示了四个抗生素管理集群. 一个使用非协议抗生素的集群,婴儿需要通风的比例更高,突出了改善抗生素管理的需要.
科学领域:
- 新生儿重症监护室新生儿重症监护室
- 传染病流行病学 传染病流行病学
- 抗微生物耐药性 抗微生物耐药性
背景情况:
- 败血症是低收入和中等收入国家新生儿死亡的主要原因,特别是在埃塞俄比亚.
- 低于最佳的抗生素管理有助于多药耐药生物体的兴起.
- 了解抗生素治疗模式对于改善新生儿败血症结果至关重要.
研究的目的:
- 在埃塞俄比亚NICU中确定新生儿败血症抗生素治疗模式的集群.
- 探索这些抗生素管理集群和败血症结果之间的关联.
主要方法:
- 从2021年4月到7月,对可能患有败血症的新生儿进行了回顾性队列研究.
- 基于使用的抗生素线及其持续时间的集群分析.
- 作为应答变量研究的死亡率和呼吸困扰.
主要成果:
- 在196名可能患有败血症的新生儿中,确定了四个抗生素管理集群.
- 大多数 (74.4%) 仅使用第一个抗生素线,没有开关.
- 一个较小的群体 (7.7%) 转换为非协议抗生素,并显示出更高的婴儿在出生时没有呼吸,需要口袋通风的比例.
结论:
- 在这种情况下,新生儿败血症的抗生素治疗涉及各种切换模式.
- 集群分析提供了对抗生素使用的见解,以及与结果的潜在联系.
- 这种方法可以支持抗生素管理,并在资源有限的地区打击抗菌素耐药性.
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